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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Development of effective procedures for transplantation of insulin-producing tissue
 Hladíková, Zuzana ; Saudek, František (advisor) ; Kvapil, Milan (referee) ; Průhová, Štěpánka (referee)
Our research has been focused on a new method of transplantation of islets of Langerhans into the greater omentum. Transplantation of pancreatic islets is an established treatment option for selected patients with unstable diabetes. The liver is almost exclusively used as a site for islet transplantation in the clinical setting. Unfortunately, immediately after graft implantation into the portal circulation, a substantial portion of the islets is lost and graft function in the liver may further deteriorate over time. The fate and location of islets implanted in the liver can only be followed with difficulty by radiological methods or biopsies. All these limitations have led to the search for alternative sites for transplantation. The greater omentum is easily surgically accessible, meets the demands of a high blood supply and can accommodate large volumes of transplanted tissue. However, the metabolic function of the islet graft itself in the omentum without fixation never achieved satisfactory long-term results in the experiment. Tissue engineering techniques have been used to improve graft attachment and maintain long-term function in the omentum. In our project, we transplanted islets into the rat omentum using a biocompatible gel consisting of recipient plasma and human thrombin....
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