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Voltammetric Determination of Nimesulide Using Graphite Composite Electrode
Hubáčková, Monika ; Vyskočil, Vlastimil (advisor) ; Fischer, Jan (referee)
This Diploma Thesis deals with the study of the electrochemical behaviour of the nonsteroidal anti-inflammatory drug nimesulide. The aim of this work is to find optimal conditions for the determination of nimesulide using voltammetric techniques direct current voltammetry (DCV) and differential pulse voltammetry (DPV) in oxidation and reduction potential regions. An ultra-trace graphite electrode (UTGE) was used as the working electrode. The pH dependence was measured to select the optimal pH, the probable mechanism of reactions was determined, the repeatability of the measurements was checked, and finally the calibration dependences were constructed and evaluated in the selected media. BR buffer media of pH 2 and 4 for DCV and pH 2 and 5 for DPV were selected to measure calibration curves in the concentration range of 0.1-100 µmol L−1 . The detection limits for both methods DCV and DPV at the UTGE were in order of about 10−7 mol L−1 , which are values corresponding to alternative voltametric methods that also use unmodified working electrodes.
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Voltammetric Behavior of the Heterogeneous Graphite Composite
Šebková, Světlana
Graphite composite electrodes offer high chemical inertness, which is accompanied by a wide range of working potentials (the widest range of potentials was obtained using CE30 in borax buffer - almost 4 000 mV). Graphite composite electrodes find the field of application mostly in the work in the area of considerably positive potentials (e.g. oxidation of adenine, guanine, aminonaphtalene, etc.), and they offer unique possibilities analytical measurements.
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