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Transport of pharmaceuticals in model hydrogels
Horváth, Michal ; Enev, Vojtěch (referee) ; Klučáková, Martina (advisor)
This thesis was devoted to the transport properties of diclofenac in model hydrogels. Gels were prepared from agarose and some were enriched with IHSS Elliott Soil humic acid. The addition of humic acid to the hydrogel should mimic the soil environment. And it was the soil environment that was chosen to observe the transport and transfer of diclofenac. Diffusion was observed in diffusion cells, where one part contained diclofenac solution and the other MQ water. And there was a hydrogel between the cells. Samples were taken from both cells and measured spectrophotometrically at different time intervals until equilibrium was established. These measurements were finally used to describe the movement of diclofenac in the hydrogels.
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Diffusion Tensor Measurement
Hrmel, Martin ; Steinbauer, Miloslav (referee) ; Bartušek, Karel (advisor)
The aim of this bachelor thesis is to create methodology for measuring diffusion tensor using MR and experimental verification on chosen biological sample. A set of samples was measured. At first, diffusion of the set of samples was evaluated, then diffusion tensors was evaluated on onion's sample by using programs Marevisi and Matlab. To obtain image a magnetic resonance was used.
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Transport properties of hyaluronan-based hydrogel systems
Káčeríková, Martina ; Smilek, Jiří (referee) ; Klučáková, Martina (advisor)
This bachelor thesis deals with the study of trasport properties of hydrogels, that were prepared by interaction of hyaluronan with karbethopendecinium bromide (Septonex), as a surfactant. Nile red is a fluorescent probe to determine the ability of the system to absorb or to release the substance. All the hydrogels were prepared by the „wet“ way, where the solutions of hyaluronan and surfactant were prepared first. Nile red was prepared in the solution of tenzide, which after the mixing with hyaluronan produced colorful gels. By the spectrophotometric measurement, the absorbance of supernatants were observed. The absorbance was measured in original but also in changed supernatatns after 24, 72 and 168 hours.
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Analysis of MR data
Guzmická, Lea ; Mézl, Martin (referee) ; Fabíková, Veronika (advisor)
The object of the work is diffusion MRI. The work deals with it from acquisition methods to postprocessing methods. The thesis is divided into 7 chapters. These gradually focus on the basic principles of MRI, measuring parameters, the phenomenon of diffusion and various methods of dMRI. The second part is comparing dMRI softwares and direct on actual postprocessing and analysis of data of study comparison of heathy controls and patients suffering eating disorders.
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Methodology for experimental study on the release of humic acids from hydrogel application forms.
Palanová, Veronika ; Klučáková, Martina (referee) ; Sedláček, Petr (advisor)
Hlavnou náplňou bakalárskej práce bolo navrhnúť a optimalizovať metódu experimentálneho štúdia uvoľňovania huminovej látky z gelových matríc, ktoré boli vytvorené pomocou bežných kozmetických a farmaceutických zahusťujúcich látok. Pre štúdium uvoľňovania tejto aktívnej látky bola zvolená difúzna aparatúra vo vertikálnom usporiadaní, tzv. Francova cela. Výluhy gelových vzoriek boli podrobené spektrofotometrickým meraniam. Vzniklé interakcie medzi roztokmi lignohumátu a rôznych typov zahusťujúcich látok boli experimentálne stanovené. Celý proces optimalizácie metódy pre uvoľňovanie huminovej látky z gelových foriem bol diskutovaný.
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Transport properties of humic hydrogels
Horváth, Michal ; Smilek, Jiří (referee) ; Klučáková, Martina (advisor)
This bachelor’s thesis is focused on the transport properties of humic hydrogels. Diffusion was observed in cuvettes containing gels prepared from agarose and organic dyes, namely Methylene Blue and Rhodamine 6G. Some of them were enriched with humic acid IHSS Leonardite. The time course of changes in concentration in individual cuvettes was recorded spectrophotometrically at different positions of the cuvette. The concentration of released dyes was simultaneously measured in the leachate. The aim of this work was to determine the effect of the presence of humic acid on the diffusion process cuvettes and to determine its flow.
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Diffusion characterization of hydrogels at microscopic level
Uher, Tadeáš ; Smilková, Marcela (referee) ; Sedláček, Petr (advisor)
This Bachelor’s thesis deals with study of diffusion in gels on microscopic level. The method of fluorescence correlation spectroscopy is used for the study of diffusion and this method is based on monitoring the diffusion coefficients in a confocal volume of studied substance. As fluorescence probe is used organic pigment called Rhodamin 6G and diffusion experiments are realized in hydrogel matrix, whose medium forms thermoreversible linear polycarbohydrate – agarose, with addition of reactive component – biopolymer called sodium polystyrenesulphate in certain concentrations. The purpose of the thesis is to research the impacts of interaction between diffusing pigment and specific type of hydrogel. The change of final diffusion coefficient is observed. It is assumed, that sodium polystyrenesulphate influences the diffusion of fluorophore (Rhodamin 6G) in agarose hydrogel.
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Methods of hydrogen charging of steels for an experimental purposes
Gordiak, Michal ; Němec, Karel (referee) ; Válka, Libor (advisor)
Bachelor thesis deals with the issue of hydrogen charging. The first part of the thesis describes individual methods, by which experimental materials are charged with hydrogen today. There are also included results of hydrogen charging experiments available in literature, achieved by described methods. The second part of the thesis is focused on techniques for analyzing hydrogen in metals and measuring surface or overall concentration of hydrogen in specimens.
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