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Nutrigenomic analysis of diet influence in prenatal and early development on metabolic syndrome aspects manifestation in adulthood.
Školníková, Elena ; Šeda, Ondřej (advisor) ; Černá, Marie (referee) ; Malínská, Hana (referee)
16 Abstract The rising prevalence in noncommunicable diseases worldwide calls for the effort to determine their underlying causes. Common metabolic disorders in particular overwhelm the healthcare systems and are a one of the leading causes of poor quality of life of patients. Metabolic syndrome is represented by concurrence of several conditions - dyslipidaemia, obesity, hypertension or impaired glucose tolerance - altered metabolic phenotypes related to genetic and environmental factors. Recent studies suggest that early-life exposure to certain environmental stimuli is particularly capable of changing the mammalian phenotypes. Nutrition, as one of the major factors influencing health, is naturally a focus of research, which studies the link between parental diets and phenotypic alterations in offspring. The developmental origins of health and disease were historically more focused on maternal undernutrition, it is, however, more important to focus on surplus of macronutrients considering the westernization of modern diets. We propose the relevancy of not only the amount of macronutrients in maternal diet, but also their sources, as they may increase disease risk in offspring. Here we report, that sucrose as an alternative carbohydrate in maternal diet, has a marked impact on metabolism of the offspring...
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The Alchemy like the Gate to Luck
Erös, Roman ; Čechura, Jaroslav (advisor) ; Zdichynec, Jan (referee)
Synopsis The aim of this Bachelor thesis is not rendered and reveal the alchymist procedures, but rather to know the thinking of the alchemists and their destinies, because not all of them were con artists who would like to share the fraudulent ways and so enrich at the expense of its surroundings. A few of them not only made money, but even borrowed, and eventually ended up in prison. Most of them really believe in their dreams of actinide transmutation and extending the life and the other on the contrary, have ceased to believe in the miracle of riches by using the transmutation and rather started to think about whether something like that is possible and then go back to the top. And it was actually the beginning of the inquiry and that of the beginning of a new scientific discipline and chemistry. Of course, that together with the effort of the alchemists of actinide transmutation of metals, and search for the stone is associated and the destinies of famous players of this science and it, from the founder of the Herma Trismegistose to the present, because the dream of the alchemists is not foreign or today's man.
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