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3D metal printing
Vrána, Pavel ; Herčík, Tomáš (referee) ; Řiháček, Jan (advisor)
The work presents a literature search of current technologies for 3D metal printing. In the introduction, the individual methods are divided according to the forms of material into powder, wire, and string. The methods using metal powder are SLS, EBM, and DED. Other methods are ADAM, PMD, and WAAM. For each technology are described the principle, printable materials, usage, and example of the product. For methods using electric arc are described possible metal transfers and their limitations.
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Role of DD- and DED-containing adaptor proteins in apoptotic signaling
Čaja, Fabián ; Anděra, Ladislav (advisor) ; Janštová, Vanda (referee)
Proteins containing a bundle of six anti-paralel α-helices in so-called "death domain" (DD) and similar structures (DED, CARD) represent important players in apoptotic signaling. To DD/DED/CARD domains-containing proteins belong pro- apoptotic membrane receptors from the TNFR superfamily, then adaptor proteins and enzymes as proteases or kinases. These pro-apoptotic "death receptors" interact with adaptor proteins and initiator caspases containing DDs or DEDs and activate apoptotic signaling cascade. DEDs and DDs are in addition found in many proteins participating in activation of caspases or other non-apoptotic signaling. Many experimental models document that defects in and deregulations of proteins containing DDs and DEDs can have severe if not lethal consequences for an organism. Abberations in these proteins in many cases could lead to cancerogenesis, immunodeficiencies or developmental defects.
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3D metal printing
Vrána, Pavel ; Herčík, Tomáš (referee) ; Řiháček, Jan (advisor)
The work presents a literature search of current technologies for 3D metal printing. In the introduction, the individual methods are divided according to the forms of material into powder, wire, and string. The methods using metal powder are SLS, EBM, and DED. Other methods are ADAM, PMD, and WAAM. For each technology are described the principle, printable materials, usage, and example of the product. For methods using electric arc are described possible metal transfers and their limitations.
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Role of DD- and DED-containing adaptor proteins in apoptotic signaling
Čaja, Fabián ; Janštová, Vanda (referee) ; Anděra, Ladislav (advisor)
Proteins containing a bundle of six anti-paralel α-helices in so-called "death domain" (DD) and similar structures (DED, CARD) represent important players in apoptotic signaling. To DD/DED/CARD domains-containing proteins belong pro- apoptotic membrane receptors from the TNFR superfamily, then adaptor proteins and enzymes as proteases or kinases. These pro-apoptotic "death receptors" interact with adaptor proteins and initiator caspases containing DDs or DEDs and activate apoptotic signaling cascade. DEDs and DDs are in addition found in many proteins participating in activation of caspases or other non-apoptotic signaling. Many experimental models document that defects in and deregulations of proteins containing DDs and DEDs can have severe if not lethal consequences for an organism. Abberations in these proteins in many cases could lead to cancerogenesis, immunodeficiencies or developmental defects.
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