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The role of cytoskeleton in cell chirality
Jandjuková, Anna ; Libusová, Lenka (advisor) ; Soukup, Vladimír (referee)
The cytoskeleton is one of the key structures inside the cell. The cytoskeleton includes microfilaments, microtubules, intermediate filaments, and more recently, septins. Cytoskeletal proteins play a role in intracellular transport, cell movement, cell division, and other structural functions. A chiral object is one that is not identical to its mirror image. The concept of chirality is most commonly used to describe chemical molecules. Cells of living organisms are composed of molecules, most of which are chiral. In recent years, cellular chirality has been observed, likely involving the cytoskeleton. Cellular chirality refers to the cell shape, organelle positioning, stable cell movement and directionally biased growth of cell culture. The latest findings suggest a probable influence of cell chirality on the development of right-left asymmetry during the embryonic development of animals. This work summarizes current knowledge regarding the role of the cytoskeleton in establishing cellular chirality and its likely connection to the development of right-left asymmetry during embryonic development. Key words Cell chirality, cytoskeleton, embryonal development
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