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Detection of atrial fibrillation in short-term ECG
Ambrožová, Monika ; Janoušek, Oto (referee) ; Ronzhina, Marina (advisor)
Atrial fibrillation is diagnosed in 1-2% of the population, in next decades, it expects a significant increase in the number of patients with this arrhythmia in connection with the aging of the population and the higher incidence of some diseases that are considered as risk factors of atrial fibrillation. The aim of this work is to describe the problem of atrial fibrillation and the methods that allow its detection in the ECG record. In the first part of work there is a theory dealing with cardiac physiology and atrial fibrillation. There is also basic descreption of the detection of atrial fibrillation. In the practical part of work, there is described software for detection of atrial fibrillation, which is provided by BTL company. Furthermore, an atrial fibrillation detector is designed. Several parameters were selected to detect the variation of RR intervals. These are the parameters of the standard deviation, coefficient of skewness and kurtosis, coefficient of variation, root mean square of the successive differences, normalized absolute deviation, normalized absolute difference, median absolute deviation and entropy. Three different classification models were used: support vector machine (SVM), k-nearest neighbor (KNN) and discriminant analysis classification. The SVM classification model achieves the best results. Results of success indicators (sensitivity: 67.1%; specificity: 97.0%; F-measure: 66.8%; accuracy: 92.9%).
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ECG based atrial fibrillation detection
Prokopová, Ivona ; Kolářová, Jana (referee) ; Ronzhina, Marina (advisor)
Atrial fibrillation is one of the most common cardiac rhythm disorders characterized by ever-increasing prevalence and incidence in the Czech Republic and abroad. The incidence of atrial fibrillation is reported at 2-4 % of the population, but due to the often asymptomatic course, the real prevalence is even higher. The aim of this work is to design an algorithm for automatic detection of atrial fibrillation in the ECG record. In the practical part of this work, an algorithm for the detection of atrial fibrillation is proposed. For the detection itself, the k-nearest neighbor method, the support vector method and the multilayer neural network were used to classify ECG signals using features indicating the variability of RR intervals and the presence of the P wave in the ECG recordings. The best detection was achieved by a model using a multilayer neural network classification with two hidden layers. Results of success indicators: Sensitivity 91.23 %, Specificity 99.20 %, PPV 91.23 %, F-measure 91.23 % and Accuracy 98.53 %.
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Atrial fibrillation model
Ředina, Richard ; Smíšek, Radovan (referee) ; Ronzhina, Marina (advisor)
The aim of this master thesis is to create a 3D electroanatomical model of a heart atria, which would be able to perform atrial fibrillation. To control the model, the differential equations of the FitzHugh-Nagumo model were chosen. These equations describe the change of voltage on the cell membrane. The equations have established parameters. The modification of them leads to changes in the behavior of the model. The simulations were performed in the COMSOL Multiphysics environment. In the first step, the simulations were performed on 2D models. Simulations of healthy heart, atrial flutter and atrial fibrillation were created. The acquired knowledge served as a basis for the creation of a 3D model on which atrial fibrillation was simulated on the basis of ectopic activity and reentry mechanism. Convincing results were obtained in accordance with the used literature. The advantages of computational modeling are its availability, zero ethical burden and the ability to simulate even rarer arrhythmias. The disadvantage of the procedure is the need to compromise between accuracy and computational complexity of simulations.
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Cluster analysis in biosignal processing
Kalous, Stanislav ; Archalous, Tomáš (referee) ; Kolářová, Jana (advisor)
This diploma thesis deals with cluster analysis for long-term electrocardiograms (ECG) clustering. The linear filtration is used for ECG preprocessing. The ECG sign segmenting in single heart cycles is based on the detection QRS complex and consequently to an application of dynamic time warping algorithms. To an application of all these mentioned processes and to results interpretation, a program called Cluster analysis has been created in the Matlab background. The results of this diploma thesis confirm that cluster analysis is able to distinguish cardiac arrhythmias which are typical with their shape distinctness of normal heart cycles.
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High-Voltage Sources for AC Cell Electroporation
Folprecht, Martin ; Drábek,, Pavel (referee) ; Damec,, Vladislav (referee) ; Červinka, Dalibor (advisor)
This doctoral thesis deals with an application of power converters in experimental medicine. Contemporary knowledge about a relatively new electroporation method and present solutions of power converters used for this method are analyzed at this work. The main part of the thesis is focused on a design and development of a new high-voltage generator proposed to AC electroporation. The last part documents an experimental verification of its function.
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Automatic -wave detection in 12-lead ECG
Khunová, Martina ; Filipenská, Marina (referee) ; Ředina, Richard (advisor)
This bachelor thesis deals with the automatic detection of delta waves from the 12-lead ECG in Matlab. In the theoretical part, the anatomy and physiology of the heart is briefly described, the reader gets familiar with Wolff-Parkinson-White syndrome, and through the manifestations of delta waves on the electrocardiogram we come to the description of linear filters and detection of the QRS complex based on the envelope. In the first part of practical part, a QRS complex detector is constructed, which is followed by a delta wave detector. The detection of the delta wave is based on the measurement of the duration of the peak and its derivation. The detector was tested on a database which data comes from pediatric patients.
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High-Voltage Sources for AC Cell Electroporation
Folprecht, Martin ; Drábek,, Pavel (referee) ; Damec,, Vladislav (referee) ; Červinka, Dalibor (advisor)
This doctoral thesis deals with an application of power converters in experimental medicine. Contemporary knowledge about a relatively new electroporation method and present solutions of power converters used for this method are analyzed at this work. The main part of the thesis is focused on a design and development of a new high-voltage generator proposed to AC electroporation. The last part documents an experimental verification of its function.
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Atrial fibrillation model
Ředina, Richard ; Smíšek, Radovan (referee) ; Ronzhina, Marina (advisor)
The aim of this master thesis is to create a 3D electroanatomical model of a heart atria, which would be able to perform atrial fibrillation. To control the model, the differential equations of the FitzHugh-Nagumo model were chosen. These equations describe the change of voltage on the cell membrane. The equations have established parameters. The modification of them leads to changes in the behavior of the model. The simulations were performed in the COMSOL Multiphysics environment. In the first step, the simulations were performed on 2D models. Simulations of healthy heart, atrial flutter and atrial fibrillation were created. The acquired knowledge served as a basis for the creation of a 3D model on which atrial fibrillation was simulated on the basis of ectopic activity and reentry mechanism. Convincing results were obtained in accordance with the used literature. The advantages of computational modeling are its availability, zero ethical burden and the ability to simulate even rarer arrhythmias. The disadvantage of the procedure is the need to compromise between accuracy and computational complexity of simulations.
|
|
|
ECG based atrial fibrillation detection
Prokopová, Ivona ; Kolářová, Jana (referee) ; Ronzhina, Marina (advisor)
Atrial fibrillation is one of the most common cardiac rhythm disorders characterized by ever-increasing prevalence and incidence in the Czech Republic and abroad. The incidence of atrial fibrillation is reported at 2-4 % of the population, but due to the often asymptomatic course, the real prevalence is even higher. The aim of this work is to design an algorithm for automatic detection of atrial fibrillation in the ECG record. In the practical part of this work, an algorithm for the detection of atrial fibrillation is proposed. For the detection itself, the k-nearest neighbor method, the support vector method and the multilayer neural network were used to classify ECG signals using features indicating the variability of RR intervals and the presence of the P wave in the ECG recordings. The best detection was achieved by a model using a multilayer neural network classification with two hidden layers. Results of success indicators: Sensitivity 91.23 %, Specificity 99.20 %, PPV 91.23 %, F-measure 91.23 % and Accuracy 98.53 %.
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Detection of atrial fibrillation in short-term ECG
Ambrožová, Monika ; Janoušek, Oto (referee) ; Ronzhina, Marina (advisor)
Atrial fibrillation is diagnosed in 1-2% of the population, in next decades, it expects a significant increase in the number of patients with this arrhythmia in connection with the aging of the population and the higher incidence of some diseases that are considered as risk factors of atrial fibrillation. The aim of this work is to describe the problem of atrial fibrillation and the methods that allow its detection in the ECG record. In the first part of work there is a theory dealing with cardiac physiology and atrial fibrillation. There is also basic descreption of the detection of atrial fibrillation. In the practical part of work, there is described software for detection of atrial fibrillation, which is provided by BTL company. Furthermore, an atrial fibrillation detector is designed. Several parameters were selected to detect the variation of RR intervals. These are the parameters of the standard deviation, coefficient of skewness and kurtosis, coefficient of variation, root mean square of the successive differences, normalized absolute deviation, normalized absolute difference, median absolute deviation and entropy. Three different classification models were used: support vector machine (SVM), k-nearest neighbor (KNN) and discriminant analysis classification. The SVM classification model achieves the best results. Results of success indicators (sensitivity: 67.1%; specificity: 97.0%; F-measure: 66.8%; accuracy: 92.9%).
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