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Detection of the HLA-B27 allele using a commercial kit
VOLKOVÁ, Simona
The main topic of the presented work is the detection of the HLA-B27 allele using a commercially available kit from the company BAG HEALTH CARE. The HLA-B27 molecule has been linked to some diseases. The best known is the association with ankylosing spondylitis or Bechterew's disease. Ankylosing spondylitis is a lifelong disease, manifested by an inflammatory reaction mainly at the site of the vertebrae of the spine and large joints such as the hips, shoulders and knees. Thanks to the association, the detection of the HLA-B27 allele can be used as a molecular marker for early diagnosis, mitigation and improvement of the course of treatment of ankylosing spondylitis. The theoretical part of the thesis specifies ankylosing spondylitis and the main histocompatibility complex with emphasis on the key molecule HLA-B27. The practical part of the bachelor thesis is focused on sample collection, DNA isolation and DNA amplification. This is followed by the laboratory detection of the HLA-B27 allele itself using a commercial kit using gel electrophoresis to visualize DNA fragments. Thus, 20 anonymized DNA samples from volunteers were examined. Of the 20 samples examined, positivity for the HLA-B27 allele was demonstrated in 6 samples of volunteers who had different clinical manifestations of Bechterew's disease.
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Kinesiotherapeutic intervention focused on patients with Bechterew's disease
VONDRŮ, Jaroslav
As a topic of my bachelor thesis I chose "Kinesiotherapeutic intervention focused on patients with Bechterew's disease". I chose this topic, because of interest and deeper knowledge of extensive problems in category: degenerative diseases of the spine. Ankylosing spondylitis, as the disease is technically called, is relatively abundant in the population and for this reason it is in my interest to contribute, at least in part, to the sorting and definition of key informations related to this rheumatic disease. In the theoretical part of this work, I focus on basic knowledge about anatomical structures related to pathophysiology of this disease. Whereas this extensive industry includes bones, muscles and fascial systems. Further I describe basic characteristics of Bechterew's disease, diagnostic criteria, clinical course and possibilities of rehabilitation or pharmacological therapy. In the practical part I deal with qualitative research activity, which focuses on a group of three patients. At the very beginning, I describe the necessary obtaining of information in the form of medical history, anthropometry and orientation examination of mobility or muscle strength. The main goal was to create an effective therapeutic program, which consists of a combination of elements of several selected rehabilitation methodologies and active, regular kinesiotherapeutic intervention within the spa concept. Information about the performed therapy, used methodologies and procedures, I present in detail in the form of elaboration of several case studies. At the end of each of them, I wrote a summary output of therapy, which includes an evaluation of the therapeutic intervention. This work can be available to the professional public, physiotherapists, available physiotherapy students to gain a basic awareness of Bechterew's disease, its pathology and possible physiotherapeutic methods.
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Case report of physiotherapeutical care for a patient with diagnosis of ankylosial spondylitis
Krausová, Zuzana ; Opatrná Novotná, Irena (advisor) ; Hassmannová, Kristina (referee)
Author: Zuzana Krausová Title: Case report of physiotherapeutical care for a patient with diagnosis of ankylosial spondylitis Objectives: The aim of this bachelor thesis is to process the diagnosis of ankylosing spondylitis and on the basis of theoretical background to develop a case report of physiotherapeutic care for a patient with this disease. Methodes: The bachelor thesis consists of two parts - general and special. The general part includes information on the anatomy and kinesiology of the spine, the field of rheumatology, spondylarthritis and ankylosing spondylitis. This information was taken from professional publications and is cited in compliance with the valid citation standard. All cited sources can be found in the chapter entitled - List of used literature. The special part is processed in the form of a case report of physiotherapeutic care for a patient with ankylosing spondylitis. This part of the bachelor thesis contains input and output kinesiological analysis, detailed description of individual therapies and evaluation of the effect of therapy. Results: The results of physiotherapeutic care result from the comparison of input and output kinesiological analysis. The results are summarized in the chapter entitled - Evaluation of the effect of therapy. During the therapies, the pain...
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The use of assistive devices for patients with Bechterev disease
KULHÁNKOVÁ, Barbora
The theoretical part of the thesis describes the actual disease. It is a rheumatic disease which includes inflammatory processes located in the spinal area. The disease is also called Ankylosing spondylitis. Typical symptom of the Bechterew's disease is stiffness and consequent back pain. Successful treatment must include use of nonsteroidal antirheumatic drugs and pain-relievers. However, the most crucial element is regular physical training, which must not be avoided otherwise the client may become permanently disabled and need assistance. The successful treatment also in cludes repeated spa stays. The thesis also deals with the role of a nurse, who together with a professional team, including physiotherapists, ergotherapists and social workers, care for the client's needs as well as for his/her education and his/her family members' education. The nurse should emphasize the importance of regular physiotherapies and use of prescribed drugs to the patients with such diagnosis. The most crucial part of the thesis deals with compensation aids which allow the clients relieving pain when moving and which get the patients back in their common lives. The patients start to use the compensation aids, such as walking sticks, wheeled walkers, and hygienic aids with long handle, in advanced stages of the disease, when common movements are difficult and painful for them. Furthermore, I am writing about the possibility of renting or purchasing such aids. There are compensation-aid rental companies and shops which offer such aids. Another part of the thesis deals with compensation allowance, which the clients may receive from their insurance companies.It also describes changes in the patient's life and environment, which may occur after receiving the compensation aids. The major goal of the thesis is to describe the possibilities of usage of compensation aids by the Bechterew's patients. To reach that I have chosen two survey questions. The first one reveals the type of compensation aids the clients prefer using and the way how they get these. The latter question explores influence of the compensation aids to the clients' lives. The survey was done by qualitative research method. For this purpose, semistructured in-depth interview was conducted with clients who suffer from the Bechterew's disease and who use compensation aids for their everyday routines. The obtained information shows that the most used aids are those which we are typical for people with movement disorders. Mostly, the clients pay for their aids by themselves. Vouchers prescribed by doctors are only used to get the forearm crutches. The Bechterew's disease is still an incurable disease. It may have very serious consequences for the patients unless they execute regular physiothe rapy, repeated spa curative stays and use the medicaments. The thesis may be used as a source material for special brochures created for mobility-impaired clients.
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