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Drug Information Centre service analysis V. - adverse drug reactions
Badura, Adam ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Drug Information Centre service analysis V. - Adverse drug reactions Author: Adam Badura Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, The Czech Republic Introduction: Drug information centre (DIC) of the Faculty of Pharmacy of Charles University and University Hospital Hradec Králové was established in 1994. Its activities include among others information provision for healthcare professionals by answering drug related enquiries. One of the main subjects of enquiries in practice are adverse drug reactions. Aim: Aim of this study is analysis of drug-related enquiries focused on adverse drug reactions processed by DIC in a period of 2015-2021. This study also includes complete answers to two drug-related enquiries that deal with adverse drug reactions. Methods: Drug related enquiries focused on adverse reactions were analysed according to factors including but not limited to the type of enquirer, age and gender of patient affected by adverse drug reactions, presence of ATC (Anatomical Therapeutic Chemical) codes, types of adverse drug reactions according to SOC (Subject Organ Class) classification, utilisation of drug information resources and recommended...
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Drug induced imbalance of sodium
Šteflová, Iveta ; Herink, Josef (advisor) ; Pourová, Jana (referee)
Iveta Šteflová Drug induced imbalance of sodium Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Department of Biological and Medical Science Supervisor: Doc.MUDr. Josef Herink, DrSc. Sodium (Na+ ) is the major extracellular cation. It plays an important role in maintaining membrane potential and depolarization that is the basic mechanism of transmission of the nerve impulse. It is involved in maintaining acid-base balance, osmotic pressure, water retention in the body. The largest part of the sodium is in the extracellular fluid where it is stored about 50 % of sodium. Plasma concentration of sodium is 140 ± 5 mmol/l. Drug-induced electrolyte disorders are increasingly reported and may be associated with considerable morbidity and mortality. The risk of drug-induced hyponatremia is generally higher than the risk of drug-induced hypernatremia. Hyponatremia is a common electrolyte disorder defined as a decrease plasma sodium concentration below 135 mmol/l. It is classified by the state of volume - hypovolemic, euvolemic and hypervolemic hyponatremia. It reflects the relative rate between sodium and water in the body. The most common cause is the syndrome of inappropriate secretion of antidiuretic hormone that induces euvolemic hyponatremia. Hypernatremia is...
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Drug induced imbalance of sodium
Šteflová, Iveta ; Herink, Josef (advisor) ; Pourová, Jana (referee)
Iveta Šteflová Drug induced imbalance of sodium Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Department of Biological and Medical Science Supervisor: Doc.MUDr. Josef Herink, DrSc. Sodium (Na+ ) is the major extracellular cation. It plays an important role in maintaining membrane potential and depolarization that is the basic mechanism of transmission of the nerve impulse. It is involved in maintaining acid-base balance, osmotic pressure, water retention in the body. The largest part of the sodium is in the extracellular fluid where it is stored about 50 % of sodium. Plasma concentration of sodium is 140 ± 5 mmol/l. Drug-induced electrolyte disorders are increasingly reported and may be associated with considerable morbidity and mortality. The risk of drug-induced hyponatremia is generally higher than the risk of drug-induced hypernatremia. Hyponatremia is a common electrolyte disorder defined as a decrease plasma sodium concentration below 135 mmol/l. It is classified by the state of volume - hypovolemic, euvolemic and hypervolemic hyponatremia. It reflects the relative rate between sodium and water in the body. The most common cause is the syndrome of inappropriate secretion of antidiuretic hormone that induces euvolemic hyponatremia. Hypernatremia is...
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