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	Molecular epidemiology and characteristics of bacterial pathogens on lung infection in patients with cystic fibrosis Vošahlíková, Šárka ; Nemec, Alexandr (advisor) ; Melter, Oto (referee) ; Osička, Radim (referee) Cystic fibrosis is the most abundant inherited autosomal recessive disease in Caucasian population. Cystic fibrosis is caused by a dysfunction of a transport channel which is responsible for the transport of chloride ions on the apical side of the plasma membrane. Despite the fact that the dysfunction of the transport channel is present in several organs, the most severely affected one is the respiratory system. Because of the ion imbalance, thick sticky mucus is produced on the surface of the airways which then prevents the removal of dust particles and bacteria. The main complications of cystic fibrosis are the bacterial infections of the respiratory system which become chronic during the patient's life and thus are the most common causes of the respiratory failure and premature death. The most important agents causing these infections are Pseudomonas aeruginosa and Burkholderia cepacia (Bcc). Infections caused by those bacteria are practically untreatable and serious complications arise from the existence of epidemic strains which can be transfered from patient to patient. Precise and fast diagnostics of pathogenic strains is a critical step to avoid spreading bacterial infections as well as strictly followed anti- epidemic strategies mainly based on isolation of cystic fibrosis patients according to... Detailed record
	IDENTIFICATION OF BURKHOLDERIA CENOCEPACIA EPIDEMIC STRAINS IN A POPULATION OF PATIENTS WITH CYSTIC FIBROSIS Vošahlíková, Šárka Detailed record
	IDENTIFICATION OF BURKHOLDERIA CENOCEPACIA EPIDEMIC STRAINS IN A POPULATION OF PATIENTS WITH CYSTIC FIBROSIS Vošahlíková, Šárka Detailed record
	Molecular epidemiology and characteristics of bacterial pathogens on lung infection in patients with cystic fibrosis Vošahlíková, Šárka ; Nemec, Alexandr (advisor) ; Melter, Oto (referee) ; Osička, Radim (referee) Cystic fibrosis is the most abundant inherited autosomal recessive disease in Caucasian population. Cystic fibrosis is caused by a dysfunction of a transport channel which is responsible for the transport of chloride ions on the apical side of the plasma membrane. Despite the fact that the dysfunction of the transport channel is present in several organs, the most severely affected one is the respiratory system. Because of the ion imbalance, thick sticky mucus is produced on the surface of the airways which then prevents the removal of dust particles and bacteria. The main complications of cystic fibrosis are the bacterial infections of the respiratory system which become chronic during the patient's life and thus are the most common causes of the respiratory failure and premature death. The most important agents causing these infections are Pseudomonas aeruginosa and Burkholderia cepacia (Bcc). Infections caused by those bacteria are practically untreatable and serious complications arise from the existence of epidemic strains which can be transfered from patient to patient. Precise and fast diagnostics of pathogenic strains is a critical step to avoid spreading bacterial infections as well as strictly followed anti- epidemic strategies mainly based on isolation of cystic fibrosis patients according to... Detailed record

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