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In vitro screening of novel potentially active antibacterial compounds III
Vízková, Marcela ; Janďourek, Ondřej (advisor) ; Voxová, Barbora (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Specialist on Laboratory Methods Autor: Bc. Marcela Vízková Supervisor: PharmDr. Ondřej Janďourek, Ph.D. Title: In vitro screening of novel potentially active antibacterial compounds III Since the discovery of penicillin, antibiotics have become part of modern therapeutic approaches. But the global spread of resistance makes their future uncertain. It is necessary to find new antibacterial substances useful in practice. As resistance is a global threat, the theoretical part deals with this issue. In addition to resistance, the theoretical part also briefly describes the antibiotics used, including new antibiotics, which were recently registered or likely to be registered. For selected groups, their mechanism of action is described in detail. Sensitivity should be determined to correctly indicate the antibiotic treatment. For this reason, the theoretical part also describes methods by which the sensitivity of a microbe to an antibiotic can be determined qualitatively or quantitatively. The theoretical part does not neglect the history of the development of antibacterial substances and familiarization with antibiotic policy in the Czech Republic. This diploma thesis is based on...
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Autoaggressive processes in thyroid gland - anamnestic study
Vízková, Marcela ; Jílek, Petr (advisor) ; Janďourek, Ondřej (referee)
This study focuses on autoimmune diseases of thyroid, which include Basedow's disease and Hasmimot's disease. Part of this research is an anamnestic study. The study was conducted via questionnaire, that was filled in by people, who suffer or used to suffer autoimmune disease of thyroid. People affected by this disease were reached predominantly via social media. The aim of the questionnaire is to find a connection between internal and external factors and outbreak of the autoimmune disease of thyroid. The results demonstrate, that high number of people affected by this disease underwent sudden mentally or physically challenging situation prior to determining the diagnosis or went through long-term stress. The study also points out to a large number of women, who were diagnosed with the autoimmune thyroiditis due to long-term use of contraceptives. Despite a large number of studies conducted in the past, no factor has been fully proven, which is one of the reasons, together with increasing number of patients, why there has been carried out more and more researches on this subject.
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