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Effectiveness of online interventions for people with compulsive sexual behavior disorder
Tučková, Barbora ; Klapilová, Kateřina (advisor) ; Urbanová, Kateřina (referee)
This bachelor thesis introduces the newly recognized diagnosis of Compulsive Sexual Behavior Disorder and maps available online interventions targeting it. The theoretical part of the thesis describes the disorder itself, including its aetiology, prevalence, ICD-11 diagnostic criteria and treatment options, and explains the concept of online interventions and their types. The second part is a systematic review which provides detailed information on existing online intervention programmes and available data on their effectiveness. The third, empirical part presents a proposal for a quantitative study on the effectiveness of the Czech version of the Hungarian-Swiss programme Hands-off, which should enhance the current knowledge on the effectiveness of low-threshold online intervention programmes for people with Compulsive Sexual Behaviour Disorder and provide first data based on clinical population from the Czech Republic. Based on all findings, the thesis presents recommendations for the implementation of a similar intervention programme in the Czech environment. Key words: Compulsive Sexual Behavior Disorder; compulsive sexuality; problematic pornography use; on-line interventions; Hands-off
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Use of liquid chromatography in pharmaceutical analysis VI.
Tučková, Barbora ; Pilařová, Pavla (advisor) ; Kastner, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Barbora Tučková Tutor: PharmDr. Pavla Pilařová, Ph.D. Title of Thesis: Use of Liquid Chromatography in Pharmaceutical Analysis VI. This diploma thesis is focused on optimization HPLC method used in University hospital Hradec Králové for determination of imatinib. Separation was performed on column: Gemini NX 5 μm C18, 150 × 4,6 mm. There was tested the influence of temperature on column, concentration of ammonium acetate, composition of the mobile phase with changing levels of organic and aqueous components and influence of flow gradient. The optimal conditions of separation were chosen: mobile phase 70% metanol-30% 10 mM amonium acetate pH 10, the flow rate 0,8 ml/min [0-1,5 min.], 1,2 ml/min [1,5-5 min.], 1,2 ml/min [5-13 min.], the detection in the UV the wavelenght of 260 nm and the temperature on the column 40 řC. At the same time extraction of imatinib from biological sample was optimized. The deproteinization and liquid-liquid extraction and ratio of hexane-ethyl acetate were tested for the analysis of biological material. Liquid-liquid extraction and 15:85 hexane-ethyl acetate were chosen as more efficient. The method was extended to other two...
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