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	Detection of antibodies reactive with F. tularensis in the early phase of infection. Straková, Kristina ; Konečná, Klára (advisor) ; Janovská, Sylva (referee) Kristina Straková Detection of antibodies reactive with F. tularensis in early phase of infection Thesis Charles University in Prague, Faculty Of Pharmacy in Hradec Králové Study program Pharmacy Because of its high virulence and mortality Francisella tularensis is considered to be a dangerous potential biological weapon and therefore this etiological agent is a suitable object of the primary research. Problems of an antibody response to the infection with intracellular pathogens are currently gaining in importance. Opinions and conclusions of various research teams differ, so this topic is up-to-date. The aim of this study was to find whether F. tularensis induces the antibody immune reaction in an early phase of infection (after 24 and 48 hours). The virulent strain of F. tularensis was used. We also intended to validate a feasibility of chosen methodology. Methods: We prepared a whole-cell bacteria lysate of F. tularensis holarctica FSC200. This lysate was separated by 2D electrophoresis with subsequent Western blotting. Proteins were marked by immunodetection using serum of BALB/c mice. Mice sera were collected 24 and 48 hours post challenge with F. tularensis. The serum of uninfected mice was utilized as control. Using comparative analysis, we tried to find proteins reacting only with the... Detailed record
	Morphological changes of sensory taste buds in pacient with cleft lip and palate Straková, Kristina ; Dušková, Markéta (advisor) The theme of my thesis morphological changessensory taste receptors in patients with cleftlip and palate, we chose based on its long-term interestthe field of plastic surgery. Cleft lip and palate defects areintegral part of this industry and one of the most interestingtopics that address this subject.The total rehabilitation of patients with cleft requiresmultidisciplinary treatment that begins immediately after birth andlasts into adulthood. The comprehensive treatment gradually, inDepending on the postnatal development, health and growthvictim, involved in a specialized team, whose base isplastic surgeon, dentist (orthodontist, maxillofacialsurgeon, dental surgeon and prosthetist), speech therapist, phoniatrist, audiologist andFinally, a clinical psychologist.Due to congenital defect area and centrofaciálníthe complexity of treatment failure also can assume the function of language,particular taste. This assumption is supported by the fact that the averagenumber of operations of the defect number reaches 4.8. Orthodontic treatmentapparatuses lasts from early childhood to prosthetic reconstructionin early adulthood. In addition, patients suffer from frequent otitis media,upper and lower respiratory tract infections and allergies. All of thesefactors can affect the function of language, particularly the... Detailed record
	Detection of antibodies reactive with F. tularensis in the early phase of infection. Straková, Kristina ; Janovská, Sylva (referee) ; Konečná, Klára (advisor) Kristina Straková Detection of antibodies reactive with F. tularensis in early phase of infection Thesis Charles University in Prague, Faculty Of Pharmacy in Hradec Králové Study program Pharmacy Because of its high virulence and mortality Francisella tularensis is considered to be a dangerous potential biological weapon and therefore this etiological agent is a suitable object of the primary research. Problems of an antibody response to the infection with intracellular pathogens are currently gaining in importance. Opinions and conclusions of various research teams differ, so this topic is up-to-date. The aim of this study was to find whether F. tularensis induces the antibody immune reaction in an early phase of infection (after 24 and 48 hours). The virulent strain of F. tularensis was used. We also intended to validate a feasibility of chosen methodology. Methods: We prepared a whole-cell bacteria lysate of F. tularensis holarctica FSC200. This lysate was separated by 2D electrophoresis with subsequent Western blotting. Proteins were marked by immunodetection using serum of BALB/c mice. Mice sera were collected 24 and 48 hours post challenge with F. tularensis. The serum of uninfected mice was utilized as control. Using comparative analysis, we tried to find proteins reacting only with the... Detailed record

See also: similar author names
4	STRAKOVÁ, Karolína
4	STRAKOVÁ, Kristýna
1	Straková, Karin
4	Straková, Karolína
4	Straková, Katarína
15	Straková, Kateřina
4	Straková, Kristýna

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