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Business Intelligence - Use of Data Mining in Business Processes
Skalický, Tomáš ; Veselý, Martin (referee) ; Kříž, Jiří (advisor)
The aim of this bachelor thesis is to get acquainted with the concept of Business Intelligence as well as with the concept of data mining and its use in the company sphere. In the introductory theoretical part I will introduce the tools of Business Intelligence and data mining methods. In the following practical part I will use the methods for analysis of provided company data. The analysis obtained can be used as a support for company decision making.
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Insight into insect trypanosomatid biology via whole genome sequencing
SKALICKÝ, Tomáš
This thesis is composed of two topics both concerning diverse and obligatory trypanosomatid parasites. First part deals with identification of new Trypanosoma species identified in blood meal of tsetse flies caught in Dzanga-Sangha Protected Areas, Central African Republic, and identification of feeding preferences of tsetse flies. The second part concerns extraordinary monoxenous trypanosomatid Paratrypanosoma confusum which constitutes the most basal branch between free-living Bodo saltans and parasitic trypanosomatids. This thesis helped to elucidate morphology and biology of this deep branching trypanosomatid. Using genome and transcriptome sequencing and comparative bioinformatics approaches enabled search for ancestral genes shared with free-living bodonids and confirmed genome streamlining in trypanosomatids.
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Predictive and prognostic factors of gastric cancer
Šmíd, David ; Skalický, Tomáš (advisor) ; Kala, Zdeněk (referee) ; Šimša, Jaromír (referee)
Predictive and prognostic factors in gastric cancer Šmíd D. Surgical clinic of University Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University in Prague. Introduction: Gastric cancer is one of malignant diseases which have the worst prognosis. Unfortunately, there are most patients with advanced-stage disease who have to be treated in a palliative way. Patients suffered from the same type of tumor, being at the same stage of disease and treated with the same chemotherapy have various rates of survival, which can be caused by diverse expression of selected genes impacting on the mechanism of cytostatic effects. The determination of these genes or microRNAs which regulate these genes could be used as a predictive factor for prediction of effects of administered chemotherapy. The determination of some microRNAs, or in the combination with suitable plasmatic factors, could be used as a prognostic factor for patients with gastric cancer. It is also possible to use this combination for early diagnosis of cancerogenesis Object: The aim is to verify the possibility to use expression of selected genes and some microRNAs in tumor tissue as a prognostic factor or a predictor for therapeutic effects of chemotherapy in patients with gastric cancer. Methodology: We retrospectively evaluated the group...
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Interactive scheduling and visualisation
Skalický, Tomáš ; Barták, Roman (advisor) ; Surynek, Pavel (referee)
The goal of this thesis was to design and implement a graphical tool for visualization and editing of schedules which would provide a function for automatic repairing of violated constraints in the schedule. The resulting application called a Gantt Viewer is integrated to the FlowOpt project that represents a complex solution for modeling workflows, creation of schedules from them and analysis of these schedules. The application has been developed with the focus on intuitiveness of the user interface and performance during the management of large schedules. It enables the user to visualize extended manufacturing schedules thanks to the cooperation with other modules of the FlowOpt project. Moreover, the Gantt Viewer incorporates a repair tool exploiting a new Repair-DTP algorithm which is both introduced and demonstrated in this work.
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Does the assesment of tumor markers in the context of the last negative conclusions still have any impact in ovarian cancer?
Svoboda, Tomáš ; Fínek, Jindřich (advisor) ; Skalický, Tomáš (referee) ; Hes, Ondřej (referee) ; Vyzula, Rostislav (referee)
Does the assessment of tumor markers in the context of the last negative conclusions still have any impact in ovarian cancer? Svoboda T.: Dept. Of Oncology and Radiotherapy, Univ.Hospital, Plzen, Czech Republic Summary: The incidence of ovarian cancer is very high in Europe and there is still a lot of encertainaity about the best screening method today. The regular use of ultrasound investigation and CA125 testing is not established as a screening, so the greatest number of patients diagnosed with this tumor has a locally advanced disease. Their prognosis is unfavourable even with the treatment by chemotherapy. We describe the role of main factors associated with the primary tumor (staging, grading, histological type) and it's treatment (surgery type and the influence of residual tumor, type and regimen of chemotherapy and inclusion of radiation therapy in the primary treatment) for disease-free and overall survival. We also confirmed that tumor markers (CA125 incl.) used in screening, during treatment measuring response to chemotherapy and for folow-up as an early predictor of disease recurrence have low specificity and sensitivity to be used today. They have role of a prognostic factor - at least some of them - unfortunately with no impact on survival even when palliative chemotherapy can start...
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Interactive Gantt Charts
Skalický, Tomáš ; Vojtáš, Peter (referee) ; Barták, Roman (advisor)
This work deals with problems of interactive rescheduling in Gantt charts. The goal of the work is to design and implement an algorithm which resolves the inconsistencies in a schedule. First existing approaches are studied. Algorithm for solving our inconsistencies in a schedule is the most important contribution of this work. It is introduced there and there is also it's proof of correctness and finiteness. Demonstration of applicability of the algorithm follows. For this reason, program GanttViewer which is a part of this work is used. Finally, this program is described in detail.
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