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Formulation and (trans)dermal application of imiquimod
Rudecká, Kateřina ; Švecová, Barbora (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Mgr. Kateřina Rudecká Consultant: PharmDr. Barbora Školová, Ph.D. Title of Thesis: Formulation and (trans)dermal application of imiquimod. Imiquimod (IMQ) is a compound of the class of heterocyclic imidazoquinolines. It exhibits significant immunomodulatory effects after topical dermal application, thus it is used advantageously in the treatment of various viral or neoplastic skin diseases. The traded preparation Aldara® containing 5% of the active substance IMQ has, despite its undeniable benefits in treatment, also a number of negative features: the price, the need for single use packets, side effects... The aim of this work was to formulate a stable dosage form for dermal administration of lower IMQ content (1%) and to compare the penetration and permeation rate of IMQ to human skin in vitro. To improve those qualities, permeation accelerants were used. Experiments were carried out in Franz's diffusion cells on human skin, with the aim of creating conditions as close as possible to those physiological. Using adhesive tapes, individual layers of the uppermost skin section (stratum corneum) were stripped, epidermis was separated from dermis and the treated tissue from the untreated one. The...
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The antiinflammatory effects of creams based on a pomegranate extract and their penetration to the skin
Rudecká, Kateřina ; Vávrová, Kateřina (advisor) ; Školová, Barbora (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Cardiff University, Cardiff School of Pharmacy and Pharmaceutical Sciences, Drug Delivery Department, Wales, United Kingdom Candidate: Kateřina Rudecká Supervisor: Doc. PharmDr. Kateřina Vávrová, Ph.D Dr. Charles M. Heard, Ph.D. Title of diploma thesis: The anti-inflammatory effects of creams based on a pomegranate extract and their penetration to the skin. To affected people, inflammatory skin diseases mean an unpleasant life experience. Unfortunately, side effects of currently the most widely used drugs for skin diseases - topically applied corticosteroids, are also often involved. That is probably why we can see a growth in the popularity of natural products in recent years. Among these hidden and newfound treasures undoubtedly belongs pomegranate, a fruit used for thousands of years and now again popularized for its antioxidant, anti-inflammatory and anticancer properties. In this study, we formulated creams consisting of Emulsifying ointment BP 15% w/w as an excipient in combination with various oils, with a focus on pomegranate seed oils (PSO, manufactured one and bought one), constituting 15% w/w. The aqueous phase containing pomegranate rind extract (PRE) made 70% w/w. These...
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