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Prediction of Protein Stability upon Mutations Using Evolution Strategy
Pavlík, David ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This master's thesis deals with the matter of predicting the effects of aminoacid substitutions on protein stability. The main aim is to design meta-classifier that combines the results of the selected prediction tools. An evolution strategy was used to find the best weights for each of the selected tools with the aim of achieving better prediction performance compared to that achieved by using these tools separately. Five different and obtainable prediction tools were selected and their prediction outputs were weighted. Two different approaches of evolution strategy are investigated and compared: evolution strategy with the 1/5-rule and evolution strategy with the type 2 of control parameters self-adaptation. Two independent datasets of mutations were created for training and evaluating the performance of designed meta-classifier. The performed experiments and obtained results suggest that the evolution strategy could be considered as a~beneficial approach for prediction of protein stability changes. However, the special attention must be paid to careful selection of tools for integration and compilation of training and testing datasets.
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Picture symbol identification with the aid of neural network
Pavlík, Daniel ; Burget, Radim (referee) ; Kohoutek, Michal (advisor)
This thesis is about using neural networks in recognition of letters A to Z and numbers 0 to 9. In the first part is theoretically described substance of neural networks and concretically described principle the method of learning multiple-layer network with backward spreaded error(a.ka Backpropagation). Basic problematic of processing the picture and resilence of network against degradation picture by a noise and compression JPEG is also described here. Second part is directed to practical realization of feed foward multiple-layer network with recognition the binary patterns of alphabetical letters and numbers 0 to 9, which was created in Matlab and Simulink environment. Next and final part is about practical realization of feed foward network with recognition the grayscale patterns of alphabetical letters and numbers 0 to 9, which was also created in Matlab and Simulink environment.
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3D Fingerprint Model Creation
Pavlík, David ; Váňa, Jan (referee) ; Dluhoš, Ondřej (advisor)
This bachelor thesis deals with acquiring fingerpints, basics of processing fingerprints at biometric systems and 3D model creation techniques. Main aim of this thesis is graphical application that uses fingerprint acquired with 2D fingerprint scanner and then creates 3D model of it. Application does not take curvature of finger into consideration but tries to reproduce height of papillary ridges. It's code is written in C++ with use of cross-platform user interface framework Qt. Besides 3D model creation it allows user to choose accuracy of this model and to export it in two different file formats. Possible use of this application is on the field of fingerprint liveness detection based on sweat pores. Application was tested on 50 real fingerprints and also on two different types of artifical fingerprints.
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Measurement of Spectral Characteristics of Fluorescent Voltage-Sensitive Dyes
Pavlík, Dušan ; Čmiel, Vratislav (referee) ; Provazník, Ivo (advisor)
This bachelor thesis deals with optical measurement of substances properties in practical service of absorption and fluorescent spectroscopy. The work specifies the principle of fluorescence, which has direct association with spectral characteristics measurement of so-called voltage-sensitive dyes (in this instance di-4-ANEPPS). This dye is used for contactless (optical) imaging of organisms electric activity in practical service of its voltage dependent spectral shift after binding itself on cell membrane. However, the right application of this fluorescent dye is dependent on too many factors – one of them, discussed and measured in this work, is di-4-ANEPPS spectral dependency on its immediate environment.
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Ultrasonic blood flow meter
Pavlík, Dušan ; Čížek, Martin (referee) ; Rozman, Jiří (advisor)
This thesis deals with ultrasound blood flow meter design with emphasis on practical implementation of such device. This medical device is used in ultrasound diagnostic, especially for measuring direction and velocity of blood flow in superficial vessels. This thesis contains consecutive design including description of individual function blocks. Documents for making double-sided printed circuit are included as well.
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Analysis of Attendance of Schools in the Town Třebíč
Pavlík, David ; Pánková, Jindřiška (referee) ; Kropáč, Jiří (advisor)
This bachelor thesis focuses on the analysis of demographic indicators of the town Třebíč. It analyzes the present state of preschool and school institutions in this town. Statistical methods of time series application are utilised here. The main objective is to make a prognosis of number of children entering kindergartens and primary schools depending on number of the born children. Predicted number is compared with the existing capacity of these institutions.
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The Proposal of Material Flow Management
Pavlík, David ; Smíšková, Hana (referee) ; Juřica, Pavel (advisor)
This master’s thesis focuses on the problematics of the material flow management in the company. Thesis is divided into the theoretical, analytical, practical and proposal part. The theoretical part defines basic concepts of selected problematics. The analytical part of the work describes the company where the thesis is processed. The practical part deals with selected indicators of the company and describes the current state of the problem. The proposal part defines possible solutions and selects the best option for the material flow management.
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Evaluation of the contribution of daylight in the hybrid lighting system
Pavlík, Denis ; Krbal, Michal (referee) ; Škoda, Jan (advisor)
The aim of the bachelor thesis is to evaluate the current status of the associated lighting system in the corridor of the building Technology university of Brno Faculty of Electrical Engineering and Communication Technic 12. The work provides the research of the lighting technologies. The second part focuses on the simulation of the associated lighting system in the computing programs Relux and Vivaldi. The evaluation of the artificial lighting system is done by hand measuring of the object and simulation of the model of the corridor in Relux. Furthermore, there is also a simulation of the associated lighting system with the contribution of daylight according to CIE for the overcast sky prepared in Relux. The simulation of the dynamic lighting scenes is adapted in Vivaldi in order to meet the criteria of standard ČSN 12464-1 for object “corridor”. The program Vivaldi put together the process of the associated lighting system in time and evaluates its economic aspects, too.
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Analysis and Optimization of Selected Business Processes
Pavlík, David ; Smíšek, Jiří (referee) ; Mazlová, Tamara (advisor)
This bachelor’s thesis focuses on the problematics of optimization of selected business processes. Thesis is divided into the theoretical, analytical and proposal part. The theoretical part defines basic concepts of selected problematics. The analytical part of the work describes the company where the thesis is processed. The practical part describes how an analysis of the current state of selected processes was done and how the optimization (improvement) of efficiency of the processes in the company ZETOR TRACTORS a.s. was designed.
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Analysis of Attendance of Schools in the Town Třebíč
Pavlík, David ; Pánková, Jindřiška (referee) ; Kropáč, Jiří (advisor)
This bachelor thesis focuses on the analysis of demographic indicators of the town Třebíč. It analyzes the present state of preschool and school institutions in this town. Statistical methods of time series application are utilised here. The main objective is to make a prognosis of number of children entering kindergartens and primary schools depending on number of the born children. Predicted number is compared with the existing capacity of these institutions.
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