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National Repository of Grey Literature 5 records found  Search took 0.00 seconds. 
Tick-borne encephalitis - from pathogenesis to therapy
 PALUS, Martin
The proposed thesis contributes to the knowledge about tick-borne encephalitis and its pathogenesis. The thesis describes pathogenesis and immunopathogenesis of tick-borne encephalitis, impact of host's genotype in clinical course determination, immune response of patients with acute tick-borne encephalitis, the mechanism of tick-borne encephalitis virus migration into central nervous system and virus interaction with cells of neurovascular unit as well as potential medical interventions.
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Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
PALUS, Martin
To address the underlying factors involved in development of tick-borne encephalitis (TBE) we developed an animal model of TBE based on BALB/c-c-STS/A (CcS/Dem) recombinant congenic mouse strains showing different severities of the infection in relation to the host genetic background. TBE virus growth, neutralizing antibody response, key cytokine and chemokine mRNA production and changes in mRNA levels of cell surface markers of immunocompetent cells in brain were measured in mice with different susceptibilities to TBE virus infection. Generated data indicate that the genetic control is an important factor influencing the clinical course of TBE.
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The role of genetic background of the host on the pathogenesis of tick-borne encephalitis
 PALUS, Martin
We examined the influence of the host genetic background on the pathogenesis of tick-borne encephalitis. We determined virus titers in organs and serum in different time intervals post-infection for different ways of inoculation. We also stated mean survival times and antibody production in different strains of mice infected with tick-borne encephalitis virus. Moreover, differences in expression of immunologicaly important genes in brains of infected mice were compared.
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Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background
 PALUS, Martin
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Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background
 PALUS, Martin
We examined the influence of host genetic and immunological background on pathogenesis of tick-borne encephalitis. We determined virus titer in organs and serum in different time intervals post-infection. In addition, we also stated mean survival times in different strains of mice with different genetic background following virus inoculation.
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See also: similar author names
1 Paluš, M.
2 Paluš, Matej
1 Paluš, Milan
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