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Converters controling
Nevoral, Jiří ; Steinbauer, Miloslav (referee) ; Fiala, Pavel (advisor)
Bachelor´s project is study of DSP microprocessor problems to converters controlling with asynchronous motors and execution of a project. Study includes information on quality single type processor, benefits and disadvantage whole solving. Of purpose is DSP converters control with DMC1500.
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Gut barrier in the pathogenesis and diagnostics of necrotizing enterocolitis and inflammatory bowel disease
Coufal, Štěpán ; Kverka, Miloslav (advisor) ; Nevoral, Jiří (referee) ; Stříž, Ilja (referee)
Disruption of gut microbiota, altered mucosal defense, inappropriate immune response and gut barrier damage are all typical features in the pathogenesis of both necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). Despite of intensive research, the exact pathogenesis of both diseases remains unclear and the diagnostics and outcome prediction are still problematic. Therefore, we analyzed the role of gut-associated and inflammatory biomarkers, with respect to different aspects of gut barrier dysfunction in the pathogenesis of both disease, with the aim to improve the diagnostics and to predict the disease course and outcome. Using ELISA, we found that patients who will later develop NEC have significantly higher intestinal fatty acid-binding protein (I-FABP) than infants who will later develop sepsis already in first hours after NEC suspicion. Urinary I-FABP had high sensitivity (81%) and specificity (100%) and its addition to currently used gold standard for NEC diagnosis increased its sensitivity and negative predictive value. We found that serum amyloid A (SAA) was the strongest factor for prediction of the most severe stage of NEC. The combination of intestinal and liver FABP with SAA predicted the length of hospitalization in NEC patients and the low level of SAA predicted short...
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Gut barrier in the pathogenesis and diagnostics of necrotizing enterocolitis and inflammatory bowel disease
Coufal, Štěpán ; Kverka, Miloslav (advisor) ; Nevoral, Jiří (referee) ; Stříž, Ilja (referee)
Disruption of gut microbiota, altered mucosal defense, inappropriate immune response and gut barrier damage are all typical features in the pathogenesis of both necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). Despite of intensive research, the exact pathogenesis of both diseases remains unclear and the diagnostics and outcome prediction are still problematic. Therefore, we analyzed the role of gut-associated and inflammatory biomarkers, with respect to different aspects of gut barrier dysfunction in the pathogenesis of both disease, with the aim to improve the diagnostics and to predict the disease course and outcome. Using ELISA, we found that patients who will later develop NEC have significantly higher intestinal fatty acid-binding protein (I-FABP) than infants who will later develop sepsis already in first hours after NEC suspicion. Urinary I-FABP had high sensitivity (81%) and specificity (100%) and its addition to currently used gold standard for NEC diagnosis increased its sensitivity and negative predictive value. We found that serum amyloid A (SAA) was the strongest factor for prediction of the most severe stage of NEC. The combination of intestinal and liver FABP with SAA predicted the length of hospitalization in NEC patients and the low level of SAA predicted short...
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Ekologie tesaříka drsnorohého (Aegosoma scabricorne (Scopoli, 1763)) (Coleoptera: Cerambycidae) na Břeclavsku
Nevoral, Jiří
This bachelor thesis deals with habitat requirements of the longhorn beetle Aegosoma scabricorne (Scopoli, 1763) in the southern Moravia. During the growing season 2015 were systematically researched the selected locations in the southern Moravia and in these localities were reported trees with occurence of this beetle. Altogether were sampled 174 trees. The occruence of A. scabricorne has been proven on 87 trees. On these trees was quantified a total number of exit holes. A total number of exit holes of A. scabricorne was 1066. Next there were recorded basic characteristics of the tree too, like type of tree, trunk circumference, tree vitality, exposure to sun and other damage of the tree. The most the longhorn beetle A. scabricorne occupied damaged trees with reduced vitality. Next the higher presence of A. scabricorne was proven on trees with breakage and with hollow. The longhorn beetle often occupied trees with larger diameter. In terms of preference exposure to sun was not proven the significant dependence here.
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Nutrition for children suffering from coeliac disease
Heniková, Marina ; Nevoral, Jiří (advisor) ; Bronský, Jiří (referee)
Coeliac disease is a systemic autoimmune disease caused by gluten occurring in genetically susceptible individuals. Clinical manifestations of coeliac disease have changed over past decades. It became more diverse and begins later. Children with common gastrointestinal symptoms are on decline while children with uncommon extraintestinal symptoms are on the rise. The high sensitivity and specificity of coeliac- specific antibodies in a group of pediatric patients with disease manifestation allowed diagnosis without biopsy. The currently used treatment for coeliac disease is lifelong strict gluten-free diet. The aim of the work was to determine the current state of knowledge of coeliac disease in children, available diagnostical methods, and treatment of coeliac disease. Furthermore, my goal was to inform about the issue of gluten-free diet, the legislation, state support, contributions of health insurers, the range and availability of gluten-free foods, their financial demands and the function of patient organizations. The aim of the practical part of my work was to find out which circumstances triggered the initial coeliac disease diagnosis in children and to inform about the problems associated with maintaining a gluten-free diet in families with children suffering from coeliac disease. The select...
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Impact of Probiotic Bacteria on Allergic Sensitization in Type I Allergy Model
Schwarzer, Martin ; Kozáková, Hana (advisor) ; Prokešová, Ludmila (referee) ; Nevoral, Jiří (referee)
The main goal in reversing the allergy epidemic is the development of effective prophylactic strategies. Early life events, such as exposures to microbes, have a major influence on the development of balanced immune responses. Due to their ability to interact with host immune system and to modulate host immune responses probiotics, mainly bifidobacteria and lactobacilli have been used with some success in prevention of allergic disease. In order to be referred to as probiotic, bacterial strain has to undergo rigorous testing. We have selected three new Lactobacillus (L.) strains out of 24 human isolates according to their antagonistic activity against pathogenic bacteria, resistance to low pH and milieu of bile salts. Safety of these strains was proven upon intragastric administration to mice; moreover, we have shown their ability to shift cytokine Th1 - Th2 balance towards non-allergic Th1 response in isolated splenic cells. Allergen specific prophylaxis using probiotics as vehicles for mucosal delivery of recombinant allergen is an attractive concept for development of well-tolerated and effective allergy vaccines. We have shown that neonatal mono-colonization of germ-free mice with the L. plantarum NCIMB8826 strain producing the major birch pollen allergen Bet v 1 attenuates the development of...
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Converters controling
Nevoral, Jiří ; Steinbauer, Miloslav (referee) ; Fiala, Pavel (advisor)
Bachelor´s project is study of DSP microprocessor problems to converters controlling with asynchronous motors and execution of a project. Study includes information on quality single type processor, benefits and disadvantage whole solving. Of purpose is DSP converters control with DMC1500.
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