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Prognostic Markers of Surgical Treatment of Malignant Lung Tumours
Skála, Martin ; Vodička, Josef (advisor) ; Kučera, Radek (referee) ; Neoral, Čestmír (referee)
Prognostic markers of surgical treatment of malignant lung tumours Summary: Introduction: Lung cancer is the most common malignancy in adults in western countries. The ideal strategy of treatment depends on early diagnosis because the clinical stage strongly impacts the prognosis. Among conventional diagnostic methods, we can analyse immunochemical markers to make the diagnosis more precise. Aim: None of the biomarkers has been evaluated sufficiently specific for one type of tumour. In our work, we tried to find a panel of immunochemical markers, which could be useful as well for the assessment of prognosis as for diagnosis. Especially in situations when taking a biopsy is impossible. The next aim of our study was to evaluate the context between clinical-pathological factors and the level of immunochemical markers and their influence on prognosis. Methods: In our study, we classified 109 patients with lung carcinoma. In the control group were also 109 persons. All 109 patients with NSCLC underwent lung resection at the Department of Surgery of University hospital in Pilsen between 17th April 2018 and 26th August 2020. Blood samples were realized on the day of operation, one week after the operation and then on day 90 and day 365. Serum level of CEA, NSE, CYFRA 21-1, MonoTotal, IGF-1, proGRP and TPS were...
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