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Vanilloid receptor TRPV1 in mechanisms of acute pain
Nováková, Karolina ; Vlachová, Viktorie (advisor) ; Kozák, Jiří (referee) ; Rokyta, Richard (referee) ; Kršiak, Miloslav (referee)
2. SUMMARY Tbe vanilloid receptor (also callcd 'capsaicin receptor') ISa nonselective catian chaLUlcl that IS predominantly exprcssed by nociceptive primary sensory neurons. This receptor was tenned vaniUoid receptor subtype 1 (TRPV I) because it became the founding member of the vanilloid receptor subfamily ortransient receptor potential (TRP) channels, a large supeďamily af nonselective cation channels that play important roles in many sensory functions. The TRPV I channel cao be activated by pungcnt vanilJoid compounds like capsaicin ar resiniferatoxln, acid (pH < 6.5), noxious heat (> 43řC), phorbol csters, endogcnous arachidonic acid derivatives, ar depolarizing voltages. Upon activation by capsaicin, TRPV 1 can regulate cellular calcium levels via direct penneatioD (PCJPN. - lO), wbich concomitantly downregulates its own activity and activates different G-protein- and phospholipase C-coupled signaling cascades. Understanding tbese underlying mechanisms is one af the key strategies that offer a way to alleviatr;: neuropathic and inflammatory pain. Although tbe molecular identificatian of tbe TRPV l channels bas greatly facilitated understanding tbc mechanisms ofthermal hyperalgesia associated with inflammation and thase by which vanilloids increase and subsequendy modulate nociceptor activity, there is...
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