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Bioactive metabolites of representative members in the genus Magnolia
Lakatošová, Ivana ; Hošťálková, Anna (advisor) ; Opletal, Lubomír (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: Ivana Lakatošová Supervisor: PharmDr. Anna Hošťálková, Ph.D. Title of Master's thesis: Bioactive metabolites of representative members in the genus Magnolia 2019, 72 p. Key words: Magnolia, secondary metabolites, traditional medicine, CNS bioactivity The aim of this Master's thesis was to summarise current knowledge of significant secondary metabolites of species Magnolia officinalis and Magnolia obovata, and their biological activity. Botanical features of genus Magnolia were defined and described, followed by the classification of bioactive compounds isolated from species Magnolia officinalis and Magnolia obovata. The Master's thesis focused predominantly on the effects of biphenol compounds of magnolol and honokiol, which have been subjected to many studies. The main attention was given to the immunosuppressive effect and pharmacologic effects on the nervous system. Essential oils were observed to have an anti-inflammatory and a myorelaxant effect. Alkaloids and neolignans, which had been known to relax spasms of skeletal muscles, expressed neuroprotective activity. Neolignans were shown to have the inhibitory effect on bacteria, viruses and pathogenic fungi. They also proved themselves to be...
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