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The role of protein kinase C in cardioprotection elicited by mild cold acclimation
Lážnovská, Lucie ; Žurmanová, Jitka (advisor) ; Hlaváčková, Markéta (referee)
This master's thesis examines the role of protein kinase C (PKC) in cardioprotection induced by mild cold. PKC is a crucial signaling transduction enzyme that regulates cell growth, differentiation, and survival of the cell. Mild cold, as a novel potential therapeutic strategy, protects tissues from ischemic damage. Studies by Yang et al. suggest that hypothermia activates PKC in cardiomyocytes, triggering a cascade of signaling pathways with protective effects. PKC phosphorylates and activates proteins crucial for cell survival and recovery after ischemia, while also inhibiting apoptosis and limiting the formation of reactive oxygen species that contribute to cell damage during ischemia and reperfusion injury. This work focuses on understanding the molecular mechanisms and signaling pathways associated with the role of PKCε and δ isoforms in cardioprotection induced by mild cold, which could contribute to the development of new therapeutic strategies protecting the heart from ischemic damage. Keywords: protein kinase C, PKCε, PKCδ, mild cold, cardioprotection
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