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Local edaphic adaptation in the Minuartia verna group
Koberová, Tereza ; Chrtek, Jindřich (advisor) ; Vít, Petr (referee)
Plants that have adapted their metabolism to life in soils containing heavy metals are suitable candidates for studying local adaptation. Although soils containing heavy metals and the plants that grow in them have attracted the attention of botanists for several decades, there is a lack of studies that address the ecological-evolutionary questions related to the pre-adaptation of plants to these challenging conditions. This work focuses on the species Minuartia verna, which includes populations growing in mine dumps, populations growing in serpentinite, and populations growing in non-toxic substrates. Local adaptation and pre-adaptation were studied using a reciprocal experiment involving populations representing each of the three aforementioned groups. I measured several vegetative and generative plant traits, fitness was then calculated based on these traits. A comparison of plant fitness of the populations grown in different soils suggests that non-metallicolous populations are not pre-adapted to grow in soils contaminated with heavy metals. However, all populations thrived well in serpentine soil, indicating a genetic adaptation to this substrate. The analysis of metal content in plants indicates that they function as excluders of Ni and Pb, with higher concentrations of these metals found in...
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Enantioselective Synthesis of BODIPY Derivatives
Koberová, Tereza ; Veselý, Jan (advisor) ; Hrdina, Radim (referee)
Chiral BODIPY derivatives are interesting substances that can be used as a source of circularly polarized fluorescence (CPL) or as stereoselective fluorescent probes. This diploma thesis deals with the preparation of enantiomerically and diastereomerically pure BODIPY derivatives using aminocatalysis. The first part of the work is focused on the reactivity of BODIPY derivatives in enantioselective Michael additions to α,β-unsaturated aldehydes activated by chiral secondary amines. The second part of the work is devoted to finding suitable reaction conditions of the cascade Michael/α-alkylation reaction to prepare chiral BODIPY derivatives with a cyclopropane ring. Subsequently, the reaction was performed with selected α,β-unsaturated aldehydes. Key words Asymetric synthesis, BODIPY, cyclopropane, Michael addition, α,β-unsaturated aldehyde, organocatalysis.
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Organocatalytic preparation of spirocycles derived from heterocycles
Koberová, Tereza ; Veselý, Jan (advisor) ; Míšek, Jiří (referee)
This bachelor work is focused on enantioselective preparation of heterocyclic spirocompounds using organocatalytic approach. First part deals with enantioselective synthesis of spirocycles by reaction of α,β-unsaturated aldehydes with heterocyclic nucleophiles under chiral secondary amin catalysis. This tandem Michael/Michael/aldol reaction is based on iminium and enamine activation of subtrate. Second part of the work is focused on the following oxidation of prepared spirocyclic aldehydes to the coresponding carboxylic acid.
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