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The impact of benzoic acids, metabolites of flavonoids, on the iron-catalysed Fenton reaction
Klenovičová, Alexandra ; Mladěnka, Přemysl (advisor) ; Karlíčková, Jana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Alexandra Klenovičová Supervisor: Prof. Přemysl Mladěnka, PharmDr., Ph.D. Consultant: Zuzana Lomozová, Ph.D. Title of diploma thesis: The impact of benzoic acids, metabolites of flavonoids, on the iron-catalysed Fenton reaction Oxidative stress is a condition in which there is an increased production of free radicals that exceeds endogenous antioxidant activity and leads to damage of biomolecules. A number of human diseases are associated with oxidative stress. However the use of antioxidants has failed in clinical trials, but it is possible that the fact that antioxidants may preferentially exhibit prooxidant activity under elevated antioxidant concentrations in various pathophysiological conditions. Various in vitro and epidemiological studies have confirmed the presence of antioxidant and prooxidant properties in flavonoids. However, on the basis of their pharmacokinetics, it is evident that after their oral intake, significant metabolism in the colon takes place, where small phenolic substances are formed in interaction with the intestinal microflora. There is a possibility that the antioxidant and harmful prooxidant properties that have been attributed to flavonoids are in fact a...
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