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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
The study of the pathogenesis of infection caused by bacteria from Burkholderia cepacia complex in patients with cystic fibrosis
 Kalferstová, Lucie ; Dřevínek, Pavel (advisor) ; Kolář, Milan (referee) ; Šebo, Peter (referee)
Summary: Bacteria from Burkholderia cepacia complex (Bcc) and bacteria Pseudomonas aeruginosa belong among the most serious pathogens causing lung infections in patients with cystic fibrosis (CF). These bacteria are highly resistant to almost all of the available antibiotics. Another serious problem is the ability of certain strains to spread among the patients, which can cause an epidemic infection. Some of the Bcc strains are capable of entering the bloodstream and causing serious septic condition called cepacia syndrome. One of these strains is the Czech epidemic strain B. cenocepacia ST32, which spread among Czech patients with CF in the 90s of the 20th century. The aim of this study was to compare transcriptome profiles of isolates gained from blood of patients with cepacia syndrome with transcriptome profiles of isolates gained from sputum of patients in the stable phase eventually exacerbation, and to choose the most appropriate genes with the different expression, which could be used as a possible marker for detection of arising cepacia syndrome. Another aim of this study was to do further study of function and influence on virulence of chosen marker (which is coding generally known virulence factor) in the time of cepacia syndrome. The last aim was to assess the epidemiologic situation of bacteria...
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Optimizing of (pro)enzyme therapy of cancer.
 KALFERSTOVÁ, Lucie
The aim of this thesis was to optimize the proenzyme and enzyme therapy of the healthy and mice suffering of cancer and to clarify the mechanism of this therapy. We found optimal mode of application of therapeutic preparations. We studied changes of serum {$\alpha$}2-macroglobulin, total level of serum protease inhibitors, and free or latent TGF-{$\beta$} in various modes of experimental tumor therapies.
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Proenzyme therapy of melanoma B16-F10
 KALFERSTOVÁ, Lucie
The aim of this study was find out the influence of proenzyme therapy and enzyme therapy on the murine melanoma B16-F10. The proenzyme therapy and enzyme therapy were compared and potential combinations were examined. In the thesis was also studied the effect of beta glucan against melanoma.
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3 KALFERSTOVÁ, Lucie
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