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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Enzyme-triggered polymer probes for fluorescence-guided surgery of solid tumors
 Horáková, Lenka ; Etrych, Tomáš (advisor) ; Kaňa, Martin (referee)
This work is focused on the synthesis of macromolecular hydrophilic polymer conjugates with fluorophores for visualization of solid tumors. These polymer probes were designed for their utilization within the image-guided endoscopic surgery, where the boundaries of the tumor tissue would be fluorescently marked after i.v. administration. Polymer carriers should provide prolonged circulation of the probe in the body and the transport of the fluorescent dye into the desired place. Polymer probes based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers prepared by radical copolymerization containing fluorescent dye cyanine7-NH2 (Cy7- NH2) were synthetized and evaluated. The dye was conjugated to the carrier via an enzymatically cleavable peptide linker, specifically Gly-Phe-Leu-Gly and Val-Cit-4-aminobenzylalcohol. The enzymatic hydrolysis of these polymer conjugates was studied using a model lysosomal enzyme cathepsin B. In vitro study was carried out using hypopharyngeal cancer cell line FaDu, in which the internalization of the probes into cells and accumulation in cell compartments was evaluated by the fluorescent confocal microscopy. Key words: nanomaterials, polymer probes, fluorescence, EPR effect [IN CZECH]
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Financial analysis Philip Morris ČR a.s.
 Káňa, Martin ; Schönfeld, Jaroslav (advisor) ; Horník, Tomáš (referee)
Financial analysis of Philip Morris ČR a.s. aims to illustrate the financial situation of the years 2005 -- 2009. There is a theoretical description of all methods applied in the first part: horizontal and vertical analysis, financial ratios and working capital, bankruptcy and financial standing models and performance evaluation of the company according to EVA. The second part describes the analyzed company, and there are applied the theoretical models. The individual results are then interpreted. In this part is the company also compared with its competitor. The final part of this work answers the question, if the company is, or is not, a financial strong company.
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8 Kaňa, Michal
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