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The role of fructose in hepatic fat accumulation
 Justrová, Marie ; Kovář, Jan (advisor) ; Malínská, Hana (referee)
One of the metabolic disorders with an increasing incidence is non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by pathological accumulation of fat in the liver. According to some authors, excessive fructose consumption plays an important role in its pathogenesis. The thesis aims to interpret published findings of the relationship between fructose intake and fat deposition in the liver. In the first part the fructose metabolism is described and compared with the glucose metabolism. The other effects of fructose on fat, carbohydrate and nucleotide metabolism are mentioned. This is followed by definition of the term NAFLD, description of various stages and clinical characterization of the disease. In the final part of the thesis the results of studies concerned with the role of excessive fructose consumption in NAFLD development are summarized. Excessive consumption of fructose by healthy subjects during isocaloric diet doesn't result in hepatic fat accumulation due to effective compensatory mechanisms. However, the role of fructose in hypercaloric diet in the increase of hepatic fat content hasn't been definitely explained yet. It seems that excessive caloric intake per se is more important than the effect of fructose or its metabolites. More pronounced rise in hepatic fat content...
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