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Study of flow and consolidation behaviour of binar mixtures of Cellets and filler for preparation of multilayer tablets
Jarolímová, Žofie ; Šklubalová, Zdeňka (advisor) ; Franc, Aleš (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Žofie Jarolímová Supervisor doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis Study of flow and consolidation behaviour of binary mixtures of Cellets and filler for preparation of multilayer tablets The manufacture and quality of solid dosage forms is influenced mainly by flow, consolidation and compaction properties of powder excipients. In this work, the behaviour of pellets made of microcrystalline cellulose (cellets), which might be used as a drug carrier in multilayer tablets, and their binary mixtures with microcrystalline cellulose was studied. More than 20 powder excipients commonly used in tablet production and their binary mixtures were involved in preliminary studies. Measuring of the angle of repose, Hausner ratio and the mass flow rate through a hopper orifice was influenced by the particle shape, size and the width of the particle size distribution. In order to identify easily the free flowing substances, the hopper orifice having 10 mm diameter was useful. Excellent flow properties were confirmed for cellets with conventional testing methods thanks to their spherical shape and narrow particle size distribution. The avalanche testing using a rotational drum...
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Study of flow and consolidation behaviour of binar mixtures of Cellets and filler for preparation of multilayer tablets
Jarolímová, Žofie ; Šklubalová, Zdeňka (advisor) ; Franc, Aleš (referee) ; Zámostný, Petr (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate Mgr. Žofie Jarolímová Supervisor doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis Study of flow and consolidation behaviour of binary mixtures of Cellets and filler for preparation of multilayer tablets The manufacture and quality of solid dosage forms is influenced mainly by flow, consolidation and compaction properties of powder excipients. In this work, the behaviour of pellets made of microcrystalline cellulose (cellets), which might be used as a drug carrier in multilayer tablets, and their binary mixtures with microcrystalline cellulose was studied. More than 20 powder excipients commonly used in tablet production and their binary mixtures were involved in preliminary studies. Measuring of the angle of repose, Hausner ratio and the mass flow rate through a hopper orifice was influenced by the particle shape, size and the width of the particle size distribution. In order to identify easily the free flowing substances, the hopper orifice having 10 mm diameter was useful. Excellent flow properties were confirmed for cellets with conventional testing methods thanks to their spherical shape and narrow particle size distribution. The avalanche testing using a rotational drum...
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