|
| |
|
|
Optimisation of the house heating by use of the renewable energy sources
Husák, Ondřej ; Frk, Martin (referee) ; Křivík, Petr (advisor)
The thesis contains is familiar with the issues of renewable energy and global warming. Assessing the use of these resources in households in the Czech Republic. The selected family house, perform measurements on the existing heating system. In conclusion, there is suggestions for optimalization system houses, the possibility of linking the with renewable energy sources and an assessment of economic turn.
|
|
|
Metabolism of inhibitors of tyrosine kinases, the drugs of new generation
Husák, Ondřej ; Indra, Radek (advisor) ; Černá, Věra (referee)
Vandetanib is orally administrated anti-cancer drug that belongs to the class of tyrosinekinase inhibitors which are used for thyroid cancer treatment. This drug undergoes biotransformation and oxidizes into two metabolites - N desmethyl vandetanib and vandetanib N-oxide. The purpose of this bachelor thesis is to compare the potency of vandetanib to vandetanib N- oxide on neroblastome cell line (UKF-NB-4); the study of metabolic process of vandetanib N- oxid and its effect on vandetanib oxidation. In this bachelor thesis we have confirmed the lower potency of vandetanib N-oxide in comparison to vandetanib. We have also discovered that vandetanib N-oxide undergoes further oxidation into another metabolite via microsomes of phenobarbital treated rats. Data suggest that in the presence of vandetanib N-oxide an increased oxidation of vandetanib to N-desmethyl vandetanib occurs. Further experiments have not confirmed this hypothesis. In higher concentrations of vandetanib, the presence of vandetanib N-oxide did not have any effect on oxidation of vandetanib to N-desmethyl vandetanib. The lower concentration led to inhibition of oxidation of vandetanib.
|
|
| |
|
|
Optimisation of the house heating by use of the renewable energy sources
Husák, Ondřej ; Frk, Martin (referee) ; Křivík, Petr (advisor)
The thesis contains is familiar with the issues of renewable energy and global warming. Assessing the use of these resources in households in the Czech Republic. The selected family house, perform measurements on the existing heating system. In conclusion, there is suggestions for optimalization system houses, the possibility of linking the with renewable energy sources and an assessment of economic turn.
|
guest ::
