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Drugs in pregnancy - strategy at selection optimal therapy and survey situation in CR
Marková, Gabriela ; Hubičková Heringová, Lucie (advisor) ; Dzúrová, Dagmar (referee)
Medication during pregnancy are frequently used for the treatment of maternal disease. Chronic diseases, like depression, anxiety, autoimmune diseases have to be treated during the pregnancy. Acute diseases, in case of need, must be treated as well. In both situation the strategy of the treatment should reflect the risk for mother and fetus. Optimal therapy is to take the effective drug for mother with minimalisation of therisk for fetus. We analyzed database of cases of prospectively followed pregnancies exposed to certain drugs and evaluate the medication with respect to the risk for the fetus. We recorded the most frequent health care providers in Czech Republic, who seek the information about risk of pharmacotherapy during pregnancy by Czech Teratology Information Service and compared the medication with optimal choice.
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Morphology and Functional Characteristics of Human Gametes - the Potencial Clinical Application
Čedíková, Miroslava ; Králíčková, Milena (advisor) ; Ludvíková, Marie (referee) ; Hubičková Heringová, Lucie (referee)
Reduced fertility is a growing problem trough the population in fertile age. It currently affects 10-15% of couples; any method of assisted reproduction cannot help 10% of them. The effort to identify new prognostic markers that would help to improve the effectiveness of treatments of infertility assumes increasing significance. The first part of this publication is focused on the study of levels of selected hormones and markers of oxidative stress in follicular fluid of women with diagnosis of infertility compared to healthy and fertile donors of oocytes. Levels of prolactin, free T3 and T4 hormone, homocysteine, malonydiladehyd, glutathione peroxidase and total antioxidant capacity and were analyzed. Next part is devoted to the difference between these parameters in women with normal body mass index (BMI) compared to women suffering from overweight. The second half of this work is focused on the male factor of infertility. The aim of our study was to determine comprehensively mitochondrial respiratory activity of sperm with normal and reduced motility and to evaluate the impact of propolis on human sperm motility. Respiratory activity of sperm was measured using oxygraph Oroboros. The results showed significantly higher levels of prolactin and free T4 hormone in follicular fluid of infertile...
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Morphology and Functional Characteristics of Human Gametes - the Potencial Clinical Application
Čedíková, Miroslava ; Králíčková, Milena (advisor) ; Ludvíková, Marie (referee) ; Hubičková Heringová, Lucie (referee)
Reduced fertility is a growing problem trough the population in fertile age. It currently affects 10-15% of couples; any method of assisted reproduction cannot help 10% of them. The effort to identify new prognostic markers that would help to improve the effectiveness of treatments of infertility assumes increasing significance. The first part of this publication is focused on the study of levels of selected hormones and markers of oxidative stress in follicular fluid of women with diagnosis of infertility compared to healthy and fertile donors of oocytes. Levels of prolactin, free T3 and T4 hormone, homocysteine, malonydiladehyd, glutathione peroxidase and total antioxidant capacity and were analyzed. Next part is devoted to the difference between these parameters in women with normal body mass index (BMI) compared to women suffering from overweight. The second half of this work is focused on the male factor of infertility. The aim of our study was to determine comprehensively mitochondrial respiratory activity of sperm with normal and reduced motility and to evaluate the impact of propolis on human sperm motility. Respiratory activity of sperm was measured using oxygraph Oroboros. The results showed significantly higher levels of prolactin and free T4 hormone in follicular fluid of infertile...
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