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Enantioselective Synthesis of BODIPY Derivatives
Koberová, Tereza ; Veselý, Jan (advisor) ; Hrdina, Radim (referee)
Chiral BODIPY derivatives are interesting substances that can be used as a source of circularly polarized fluorescence (CPL) or as stereoselective fluorescent probes. This diploma thesis deals with the preparation of enantiomerically and diastereomerically pure BODIPY derivatives using aminocatalysis. The first part of the work is focused on the reactivity of BODIPY derivatives in enantioselective Michael additions to α,β-unsaturated aldehydes activated by chiral secondary amines. The second part of the work is devoted to finding suitable reaction conditions of the cascade Michael/α-alkylation reaction to prepare chiral BODIPY derivatives with a cyclopropane ring. Subsequently, the reaction was performed with selected α,β-unsaturated aldehydes. Key words Asymetric synthesis, BODIPY, cyclopropane, Michael addition, α,β-unsaturated aldehyde, organocatalysis.
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Synthesis of axially chiral pyridin N-oxides and their application in organocatalysis
Hrdina, Radim ; Kotora, Martin (advisor) ; Černý, Miloslav (referee) ; Dvořák, Dalimil (referee) ; Starý, Ivo (referee)
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Ultrasonic and Densitometric Characterization of Hyaluronan and its Interaction with Surfactant
Hurčíková, Andrea ; Hrdina, Radim (referee) ; Mráček,, Aleš (referee) ; Pekař, Miloslav (advisor)
This disertation thesis is focused on the study of physico-chemical interactions of hyaluronan (with molecular weights from 10 to 1750 kDa) with cationic surfactants measured using uncommon technique named high resolution ultrasonic spectroscopy. Densitometer was also used for the study of these interactions, in measuring of density and ultrasonic velocity of hyaluronan with different molecular weight in dependence on elevated temperature (25 50 °C). The aim is the determination of critical micelle concentration (CMC) and critical aggregation concentration (CAC) of the suractants in the absence and in the presence of hyaluronan with various molecular weights. Interactions in this system are important for the design of the systems for the targeted delivery, especially for the drugs. The experiments were made in water and sodium chloride solution. The significant breakpoint in the ultrasonic velocity showed changes in the system hyaluronan-surfactant.
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