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Determination of ganciclovir in lung transplant recipients
Hrach, Filip ; Szotáková, Barbora (advisor) ; Kotaška, Karel (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Filip Hrach Supervisor: prof. Ing. Barbora Szotáková, Ph.D. Consultant: doc. Ing. Eva Klapková, Ph.D. Title of diploma thesis: Determination of ganciclovir in lung transplant recipients Ganciclovir is a nucleoside analogue that is widely used for the treatment of infections caused by herpes viruses, including cytomegalovirus. Patients after lung transplantation are always given valganciclovir (ganciclovir prodrug) prophylactically to prevent cytomegalovirus infection. The aim of this thesis was to establish a reliable, sensitive and rapid analytical method for the determination of ganciclovir and to validate this method. Furthermore, to determine ganciclovir levels in patients after lung transplantation. The final objective was to evaluate the importance of therapeutic monitoring of ganciclovir. A liquid chromatography-tandem mass spectrometry method was established for the determination of ganciclovir. Validation parameters necessary for bioanalytical methods have been established.All validation parameters met the conditions for successful validation.Valganciclovir is used for oral administration of antiviral drugs and ganciclovir for intravenous administration. Patients after lung...
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Determination of ganciclovir in lung transplant recipients
Hrach, Filip ; Szotáková, Barbora (advisor) ; Kotaška, Karel (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Filip Hrach Supervisor: prof. Ing. Barbora Szotáková, Ph.D. Consultant: doc. Ing. Eva Klapková, Ph.D. Title of diploma thesis: Determination of ganciclovir in lung transplant recipients Ganciclovir is a nucleoside analogue that is widely used for the treatment of infections caused by herpes viruses, including cytomegalovirus. Patients after lung transplantation are always given valganciclovir (ganciclovir prodrug) prophylactically to prevent cytomegalovirus infection. The aim of this thesis was to establish a reliable, sensitive and rapid analytical method for the determination of ganciclovir and to validate this method. Furthermore, to determine ganciclovir levels in patients after lung transplantation. The final objective was to evaluate the importance of therapeutic monitoring of ganciclovir. A liquid chromatography-tandem mass spectrometry method was established for the determination of ganciclovir. Validation parameters necessary for bioanalytical methods have been established.All validation parameters met the conditions for successful validation.Valganciclovir is used for oral administration of antiviral drugs and ganciclovir for intravenous administration. Patients after lung...
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Hand hygiene as a prevention of nosocomial infections at healthcare professionals in Nemocnice Strakonice a.s.
HRACH, Filip
This bachelor thesis deals with the prevention and monitoring of infections which are associated with the health care in Hospital Strakonice, a.s. The main goal of this thesis was to analyse and describe the current situation in area of prevention of nosocomial infections in connection with the hand hygiene of the medical staff in this hospital. The knowledge of medical staff in area of nosocomial infections, activity of persons doing the cleaning or the quality of the hand hygiene of the medical staff was the main focus. The bachelor thesis is focused on several hospital wards - haemodialysis, anaesthesiology and resuscitation, intensive care unit and finally maternity ward The bachelor thesis has two parts - theoretical and practical. The already known knowledge in area of infections connected with the health care is described in the theoretical part. The focus was on the technique, manners, quality of hand hygiene and the hand disinfection, explanation of the term nosocomial infections, classification, definition and spreading of the nosocomial infections. The information was obtained and used from Czech and foreign literature. The practical part refers to the short research and observation in Hospital Strakonice, a.s. The main goal was to find out by means of different methods the quality of hospital hygiene. The research was conducted using semiquantitative and qualitative methods. Each method in the thesis is described methodically and practically. The results were commented on in the discussion.
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