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Assessment of Risk Related to Work with Heavy Loads
Jurigová, Karolína ; Horáčková, Hana (referee) ; Popelová, Barbora (advisor)
The diploma thesis is focused on the issues of handling heavy loads using a crane. The thesis tries to identify threats in the process. Analysis of the current state evaluates the issue from the perspective of OHS not only in the Czech Republic but also in selected states of the European Union. Furthermore, the analysis discusses the obligations of employees and employers in the field of safety and clarifies the basic concepts of the issue. Based on a model example, the analyzes are performed to that identify the threats with the highest level of risk Subsequently, there are presented measures which should lead to the minimization of the level of risk for identified process threats.
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Effect of antidepressants on placental monoamine homeostasis
Horáčková, Hana ; Štaud, František (advisor) ; Sumová, Alena (referee) ; Soukup, Ondřej (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Pharmacology and Toxicology Candidate: Mgr. Hana Horackova Supervisor: prof. PharmDr. Frantisek Staud, Ph.D. Title of doctoral thesis: Effect of antidepressants on placental monoamine homeostasis Depression in pregnancy is an increasingly common problem and it is reported that up to 25 % of pregnant women suffer from depression and approximately 13 % are prescribed antidepressants. Currently, the most commonly prescribed antidepressants in pregnancy are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). However, the safety of these treatments is still controversial, as poor pregnancy outcomes such as organ malformations, increased incidence of neurological disorders, and preeclampsia have been reported in pregnant women taking antidepressants. However, knowledge of the responsible mechanisms is still lacking at present as they have not been sufficiently investigated. Although the effect of antidepressants on the availability of serotonin (5-HT), dopamine (DA) and norepinephrine in brain tissue has been extensively characterized in the literature, the interactions of antidepressants with placental monoamine transporters have not received attention to date. However,...
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Effect of sesquiterpenes on detoxifying enzymes in liver slices
Horáčková, Hana ; Szotáková, Barbora (advisor) ; Boušová, Iva (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Hana Horáčková Supervisor: prof. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Effect of sesquiterpenes on detoxifying enzymes in liver slices Sesquiterpenes are secondary metabolites produced by higher plants, bacteria and fungi. They ensure the survival and competitiveness of plants. Sesquiterpenes are composed of three isoprene units. They possess anti-inflammatory, antimalarial, antibacterial, antiviral, antioxidant, analgesic, antifungal and anticancer activity. Sesquiterpenes, the main components of plant essential oils, have been used in folk medicine and as spices for years. The aim of this diploma thesis was to find out the effect of three structurally related sesquiterpenes α-humulene (HUM), β-caryophyllene (CAR), and β-caryophyllene oxide (CAO) on the activities of the main drug-metabolizing enzymes. Precision-cut tissue slices from the rat liver (Rattus norvegicus) were chosen as model system. Thickness of the slices was 200-250 μm and diameter 8 mm. Liver slices were pre-incubated for 30 minutes and then incubated for 8 and 24 hours. Samples of liver slices and incubation medium were taken upon replacing the medium after pre-incubation (time 0 hours) and then after 8 and 24...
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Assessment of Risk Related to Work with Heavy Loads
Jurigová, Karolína ; Horáčková, Hana (referee) ; Popelová, Barbora (advisor)
The diploma thesis is focused on the issues of handling heavy loads using a crane. The thesis tries to identify threats in the process. Analysis of the current state evaluates the issue from the perspective of OHS not only in the Czech Republic but also in selected states of the European Union. Furthermore, the analysis discusses the obligations of employees and employers in the field of safety and clarifies the basic concepts of the issue. Based on a model example, the analyzes are performed to that identify the threats with the highest level of risk Subsequently, there are presented measures which should lead to the minimization of the level of risk for identified process threats.
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Effect of sesquiterpenes on detoxifying enzymes in liver slices
Horáčková, Hana ; Szotáková, Barbora (advisor) ; Boušová, Iva (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Hana Horáčková Supervisor: prof. Ing. Barbora Szotáková, Ph.D. Title of diploma thesis: Effect of sesquiterpenes on detoxifying enzymes in liver slices Sesquiterpenes are secondary metabolites produced by higher plants, bacteria and fungi. They ensure the survival and competitiveness of plants. Sesquiterpenes are composed of three isoprene units. They possess anti-inflammatory, antimalarial, antibacterial, antiviral, antioxidant, analgesic, antifungal and anticancer activity. Sesquiterpenes, the main components of plant essential oils, have been used in folk medicine and as spices for years. The aim of this diploma thesis was to find out the effect of three structurally related sesquiterpenes α-humulene (HUM), β-caryophyllene (CAR), and β-caryophyllene oxide (CAO) on the activities of the main drug-metabolizing enzymes. Precision-cut tissue slices from the rat liver (Rattus norvegicus) were chosen as model system. Thickness of the slices was 200-250 μm and diameter 8 mm. Liver slices were pre-incubated for 30 minutes and then incubated for 8 and 24 hours. Samples of liver slices and incubation medium were taken upon replacing the medium after pre-incubation (time 0 hours) and then after 8 and 24...
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