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Mechanism of hypertrophic cardiomyopathy
Hadravová, Kateřina ; Horníková, Daniela (advisor) ; Benák, Daniel (referee)
Cardiomyopathies are a group of chronic cardiac diseases of unclear etiology. We can separate them by morphological and functional signs into restrictive, dilated and hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy is a relatively common disease in which the development of cardiac hypertrophy is not based on risk factors such as hypertension or atherosclerosis. Compared to acquired cardiac hypertrophy the hypertrophic cardiomyopathy is mainly caused by hereditary mutations. These mutations are mostly in genes for myosin heavy chain β and myosin binding protein C. Cardiac hypertrophy also presents with changes in the extracellular matrix caused by matrix metaloproteinases. They have a big impact on the morphology of cardiomyocytes and their loss, which in turn cause hypertrophy or left ventricle dilation. From medical point of view emphasis is put on prevention and early diagnosis using blood biomarkers. Among singnificant biomarkers are micro-RNAses, vascular endothelial growth factor B, NAD - dependent deacetylase sirtuin-3, growth/differentiation factor 15, glycoprotein 130 and calmodulin - dependent proteinkinase II. Causal treatment doesn't unfortunately exist, therefore symptomatic treatment is deployed using β blockers and calcium channel blockers. Newly used drugs include an...
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The History of Easter Traditions and Patterns of Easter eggs in the Jindřichův Hradec Region.
HADRAVOVÁ, Kateřina
Abstract The theoretical part of the graduation thesis deals with Easter holidays, customs and traditions. It focuses mainly on the history and development of Easter eggs and especially in the Jindřichův Hradec region. It describes the techniques and tools that are used to decorate Easter eggs. It documents the Easter eggs patterns typical for this region and introduces some creators. In the practical part of the graduation thesis the author created, based on previous documentation and consultation with the creators of Easter eggs, samplers of own motives. The first sampler is based on the so-called "blatské straky" patterns and builds on some of the traditional patterns of the region. The second one is inspired by nature and it is the artistic stylization of flowers and leaves. Both samplers are for inspiration for creative work in creative clubs or school environment. Also they should help to maintain the traditional Easter customs.
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Mobility and It´s Social Meaning
Hadravová, Kateřina ; ŽIŽKA, Tomáš (advisor) ; MATÁSEK, Petr (referee)
This thesis deals with the possibilities of scenic mobility and its social meaning especially to a group of realizators and the local community. Text is a summary of the overall creative and technical solution of projects Cantalon as a part of the festival Histeria and Roaming theater that arose during the master's program KALD department of Stage design in 2011-2012. Emphasis is given on the needs and opportunities in the development and implementation of mobile authors projects.
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