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The role of DNA damage in cellular senescence
Dušková, Pavlína ; Vondrejs, Vladimír (referee) ; Hodný, Zdeněk (advisor)
Cells grown in vitro may be introduced into terminal growth arrest termed cellular senescence. In normal cells, it always arises when they reach the end of their proliferative capacity. However, this process may be also caused by various means anytime during the cultivation of both normal and at some circumstances also in immortal cells. Current view of cellular senescence places this phenomenon into direct relationship with DNA damage. The first aim of this study is to elucidate the role of DNA damage in chemically induced senescence. Until recently, DNA damage was not studied in this particular model. All chemicals used in this work are routinely used to unveil unstable parts of the human genome, so called fragile sites, which are inherently prone to DNA breakage. The second aim of this study is to asses the possibility that these sensitive regions of DNA might be also involved in senescent phenotype. Two of the three chemicals used in this study, 5-bromodeoxyuridine and distamycin A, were commonly used to accomplish senescence, and their effect on main senescence-associated changes in cellular proteome is thus relatively well defined. The changes caused by the third compound, thymidine, were so far poorly investigated. Therefore, the last aim of this work is to find out, if the changes of protein...
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Hispanistics in the Journal for Modern Philology.
DUŠKOVÁ, Pavlína
The present diploma thesis gives an overview of hispanistic topics in the Journal for Modern Philology with emphasis on the period after 1953. The work is divided into three parts. The first and largest part is devoted to the chronological overview of the above-mentioned topics. The second part examines the thematic lines appearing in the journal and the third part provides brief profiles of contributors who published articles with hispanistic topics. The appendix to this work contains a list of all hispanistic contributions in the Journal for Modern Philology from 1911 to 2014 with some additional information.
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Past and present of Spain in the sight of the Czech Hispanism
DUŠKOVÁ, Pavlína
The thesis "Past and present of Spain in the sight of the Czech Hispanism" deals with evolution of Czech Hispanic studies that research history of Spain and Czech-Spanish relationships since the late 19th century until now. The whole work is divided into four fundamental chapters. The first chapter introduces Czech hispanists - historians by the year 1945. The second chapter is devoted to the most important persons of Czech Hispanism after 1945. The third chapter is looking for the feedback for works of Czech hispanists ? historians abroad.The fourth chapter relates Czech Hispanic studies to different European Hispanisms and discusses the existence of coincidence with other countries' trends.
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