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National Repository of Grey Literature 5 records found  Search took 0.00 seconds. 
Optimalization of DNA extraction from plant material for subsequent PCR analyses
 Kučabová, Veronika ; Fér, Tomáš (advisor) ; Chudoba, Richard (referee)
Detailed record
Determination of enantiomers of selected drugs by HPLC
 Geryk, Radim ; Tesařová, Eva (advisor) ; Chudoba, Richard (referee)
Drugs are often chiral compounds. In many cases only one of the enantiomers has required therapeutical effects. Citalopram belongs to a group of chiral drugs. This drug is used as an antidepresivum for treating anxiety, fear or suppressing of pain feeling. Its synthetical precursor is named citadiol and this compound is also chiral. HPLC method with chiral stationary phases based on macrocyclic antibiotics was applied for enantioseparation of above-mentioned compounds. Polar-organic and ionic-polar separation modes were found to be suitable for chiral separation of citalopram and citadiol enantiomers. The aim of this work was monitoring of enantioseparation "behaviour" of selected enantiomers and to find suitable separations conditions using HPLC method.
Detailed record
Electrophoretic separation of normal and mutant DNA in partially denaturating conditions
 Chudoba, Richard ; Gaš, Bohuslav (advisor) ; Klepárník, Karel (referee)
Detailed record
Optimalization of DNA extraction from plant material for subsequent PCR analyses
 Kučabová, Veronika ; Chudoba, Richard (referee) ; Fér, Tomáš (advisor)
Detailed record
Determination of enantiomers of selected drugs by HPLC
 Geryk, Radim ; Chudoba, Richard (referee) ; Tesařová, Eva (advisor)
Drugs are often chiral compounds. In many cases only one of the enantiomers has required therapeutical effects. Citalopram belongs to a group of chiral drugs. This drug is used as an antidepresivum for treating anxiety, fear or suppressing of pain feeling. Its synthetical precursor is named citadiol and this compound is also chiral. HPLC method with chiral stationary phases based on macrocyclic antibiotics was applied for enantioseparation of above-mentioned compounds. Polar-organic and ionic-polar separation modes were found to be suitable for chiral separation of citalopram and citadiol enantiomers. The aim of this work was monitoring of enantioseparation "behaviour" of selected enantiomers and to find suitable separations conditions using HPLC method.
Detailed record

See also: similar author names
1 Chudoba, Rudolf
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