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Possibilities of aggregometry in antiplatelet prevention of strokes. Relationship between reduced aggregation and stroke risk prevention.
 Chýlová, Miroslava ; Kalvach, Pavel (advisor) ; Tomek, Aleš (referee) ; Herzig, Roman (referee)
Background. This dissertation offers an overview of knowledge about platelets, the principle of platelet aggregation, its reduction by antiplatelet drugs and anticoagulation, methods of measuring platelet aggregation and views on resistance to acetylsalicylic acid. The effectiveness of ASA (acetylsalicylic acid) in prevention of vascular events is usually derived indirectly from comparison of individuals taking placebo and not from the results of aggregometric methods. The purpose of our work was 1) to assess the effect of different doses and different routes of ASA administration on platelet aggregation, 2) to compare results of two different aggregometry methods and 3) to assess the effect of anticoagulation treatment on platelet aggregation in patients with chronic ischemic heart disease. Methods. The first study group consisted of 22 healthy individuals and 30 patients with documented ischemic stroke. Platelet aggregation was measured before ASA application and then after different doses and different routes of ASA administration. In the second study the group consisted of 30 patients with documented ischemic stroke who were taking orally 100mg ASA daily. We compared platelet aggregation measured by VerifyNow and by light transmission aggregometry (LTA) using different agonists. In the third...
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