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Rheology of Hyaluronan Solutions
Bilerová, Helena ; Porkorný,, Marek (referee) ; Lehocký,, Marián (referee) ; Pekař, Miloslav (advisor)
Předložená práce se zabývá reologickými vlastnostmi roztoků hyaluronanu. Studuje chování hyaluronanových roztoků v prostředí několika rozpouštědel, dále se zabývá vlivem měnícího se pH a rostoucí teploty na viskozitu roztoků. V neposlední řadě je zkoumána správná příprava roztoků, jejich časová stabilita a tvorba agregátů.Všechny experimenty vycházejí z praktického upotřebení, např. při výrobě hyaluronanu, jeho sterilizaci a následném skladování roztoků.
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Stability of humic acids in production of eye drops
Lišková, Kateřina ; Mravec, Filip (referee) ; Bilerová, Helena (advisor)
Glykoaminoglykans are the biological active compounds, which significantly affect the physiological processes in living organisms from under low concentrations. Marked representative of this group is hyaluronic acid. It is linear polysacharid, whose primary structure is consists of D-glucuronic acid and N-acetyl-D-glucosamin linking by glycosidic bonds (13) and (14). It is occurring connective tissues, synovial fluids and vitreous humor too, in which forms system with unique rheological and optical properties. Except of human body is its concentration especially high in the cockscombs. Hyaluronic acid has very high ability to bonding molecules of water, increasing molecular weight a then viscosity of aqueous solutions too. This fact together with characteristic viscoelasticity and lubricating properties plays an important role in preserve of organism. Acid, but its salt too form basic component of compounds using in ophthalmic surgery. It is using in extraction of cataract, operation of glaucoma, implantation of crystalline lens and corneal grafting too. Aim of this bachelor work was a determination of stability of hyaluronic acid solutions along the production of eye drops. Main objective was using by rheological measurement detect the influence of addition polymers (PVP, PACA, PEOX, PEG, PUD, PEI) and different pH on stability, degradation aqueous solution of hyaluronic acid at sterilization in the steam autoclave respectively.
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Rheology of Hyaluronan Solutions
Bilerová, Helena ; Porkorný,, Marek (referee) ; Lehocký,, Marián (referee) ; Pekař, Miloslav (advisor)
Předložená práce se zabývá reologickými vlastnostmi roztoků hyaluronanu. Studuje chování hyaluronanových roztoků v prostředí několika rozpouštědel, dále se zabývá vlivem měnícího se pH a rostoucí teploty na viskozitu roztoků. V neposlední řadě je zkoumána správná příprava roztoků, jejich časová stabilita a tvorba agregátů.Všechny experimenty vycházejí z praktického upotřebení, např. při výrobě hyaluronanu, jeho sterilizaci a následném skladování roztoků.
|
|
|
Stability of humic acids in production of eye drops
Lišková, Kateřina ; Mravec, Filip (referee) ; Bilerová, Helena (advisor)
Glykoaminoglykans are the biological active compounds, which significantly affect the physiological processes in living organisms from under low concentrations. Marked representative of this group is hyaluronic acid. It is linear polysacharid, whose primary structure is consists of D-glucuronic acid and N-acetyl-D-glucosamin linking by glycosidic bonds (13) and (14). It is occurring connective tissues, synovial fluids and vitreous humor too, in which forms system with unique rheological and optical properties. Except of human body is its concentration especially high in the cockscombs. Hyaluronic acid has very high ability to bonding molecules of water, increasing molecular weight a then viscosity of aqueous solutions too. This fact together with characteristic viscoelasticity and lubricating properties plays an important role in preserve of organism. Acid, but its salt too form basic component of compounds using in ophthalmic surgery. It is using in extraction of cataract, operation of glaucoma, implantation of crystalline lens and corneal grafting too. Aim of this bachelor work was a determination of stability of hyaluronic acid solutions along the production of eye drops. Main objective was using by rheological measurement detect the influence of addition polymers (PVP, PACA, PEOX, PEG, PUD, PEI) and different pH on stability, degradation aqueous solution of hyaluronic acid at sterilization in the steam autoclave respectively.
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