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Immunohistochemical and Molecular Genetic Methods in the Head and Neck Pathology
Baněčková, Martina ; Skálová, Alena (advisor) ; Stárek, Ivo (referee) ; Laco, Jan (referee)
Current doctoral thesis is dealing with morphology, immunohistochemistry, molecular genetics and biological behavior of head and neck tumors with a particular emphasis on salivary gland and sinonasal lesions. Dr. Martina Baneckova has focused on this topic during her postgraduate studies at Charles University, Medical Faculty in Pilsen, in the years 2017 - 2020. In her publication activity, the author focused on rare tumors of the head and neck. A total of 9 publications were published over a span of three years are presented in a form of a commentary. Four of them are first-author papers and these are introduced briefly below. The first study entitled "Mammary analog secretory carcinoma of the nasal cavity: Characterization of 2 cases and their distinction from other low-grade sinonasal adenocarcinomas" deals with the relationship of newly described entities, secretory carcinoma (SC) of the nasal cavity and ETV6-rearranged low-grade sinonasal adenocarcinoma (LG SNAC). It is important to distinguish these 2 entities because of different clinical behaviors. Low-grade non-ITAC, including ETV6-rearranged LG SNAC mostly behave in an indolent manner, whereas SC is a malignancy with metastatic potential. It is important to be aware of the possible occurrence of SC in the sinonasal region, as in this area...
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