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Endogenous markers in the etiopathogenesis of abdominal aortic aneurysms
Houdek, Karel ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Šebesta, Pavel (referee) ; Staffa, Robert (referee)
Introduction Prevalence of abdominal aortic aneurysm is 2-6%. Aneurysm is on the leading possitions in death cause. Lot of patients die do to ruptured aneurysm. The etiology of abdominal aortic aneurysm remains unknown. Current treatment(resection or endovascular)is not indicated for everyone. We don't know the right conservative (pharmacological) treatment. Aims With our study, we would like to confirm the impact of atorvastatin on experimental abdominal aortic aneurysm. We would like to evaluate and quantified changes in the composition of an aneurysmatic wall under the effect of atorvastatin. Other aim is to make a summary of known knowledge of this disorder. These knowledges can help in searching for new treatment options. Methods Comparison of 2 groups of pigs with experimental abdominal aortic aneurysm. Group treated with atorvastatin and group without any pharmacological influencing. Comparing of aneurysmal growth rate. Evaluation of changes of the wall structure in both groups using a stereological tools. Review of published data. Results In our experimental work atorvastatin did not slow down the growth of the aneurysm. Effect was on the histological structure of the aneurysmatic wall. Wall structure of the aneurysm in group treated with atorvastatin was really close to wall without any...
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Perfusion of a Kidney Graft from a Donor After Cardiac Death Based on Immediately Started Pulsatile Machine Perfusion
Opatrný, Václav ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Havránek, Pavel (referee)
Immediately started pulsatile machine perfusion of a kidney graft from a DCD (donor after cardiac death) as a way to improve its properties Opatrný V. Department of Surgery, University Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University in Prague Introduction: The number of kidneys available for transplantation still does not match the number of patients on the waiting list, which gets longer every year. At the same time, kidney transplantation is the only chance for the long-term survival of patients with good quality of life. Therefore, organs from marginal donors, including donors after cardiac death (DCD), have recently been used. The most common cause of death of these donors is severe trauma, especially craniocerebral trauma, or sudden cardiac arrest, followed by unsuccessful resuscitation. Kidneys can be harvested once an individual is declared dead according to the exact criteria. This involves initial washing of the grafts in the donor's body using a perfusion solution, followed by their removal and storage using selected preservation method. Mechanical pulsatile perfusion using special instrumentation is the most frequently used technique in the area of DCD. Despite of good long-term outcomes of grafts from DCDs, this group is burdened by a greater number of delayed graft...
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Perfusion of a Kidney Graft from a Donor After Cardiac Death Based on Immediately Started Pulsatile Machine Perfusion
Opatrný, Václav ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Havránek, Pavel (referee)
Immediately started pulsatile machine perfusion of a kidney graft from a DCD (donor after cardiac death) as a way to improve its properties Opatrný V. Department of Surgery, University Hospital in Pilsen and Faculty of Medicine in Pilsen, Charles University in Prague Introduction: The number of kidneys available for transplantation still does not match the number of patients on the waiting list, which gets longer every year. At the same time, kidney transplantation is the only chance for the long-term survival of patients with good quality of life. Therefore, organs from marginal donors, including donors after cardiac death (DCD), have recently been used. The most common cause of death of these donors is severe trauma, especially craniocerebral trauma, or sudden cardiac arrest, followed by unsuccessful resuscitation. Kidneys can be harvested once an individual is declared dead according to the exact criteria. This involves initial washing of the grafts in the donor's body using a perfusion solution, followed by their removal and storage using selected preservation method. Mechanical pulsatile perfusion using special instrumentation is the most frequently used technique in the area of DCD. Despite of good long-term outcomes of grafts from DCDs, this group is burdened by a greater number of delayed graft...
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Endogenous markers in the etiopathogenesis of abdominal aortic aneurysms
Houdek, Karel ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Šebesta, Pavel (referee) ; Staffa, Robert (referee)
Introduction Prevalence of abdominal aortic aneurysm is 2-6%. Aneurysm is on the leading possitions in death cause. Lot of patients die do to ruptured aneurysm. The etiology of abdominal aortic aneurysm remains unknown. Current treatment(resection or endovascular)is not indicated for everyone. We don't know the right conservative (pharmacological) treatment. Aims With our study, we would like to confirm the impact of atorvastatin on experimental abdominal aortic aneurysm. We would like to evaluate and quantified changes in the composition of an aneurysmatic wall under the effect of atorvastatin. Other aim is to make a summary of known knowledge of this disorder. These knowledges can help in searching for new treatment options. Methods Comparison of 2 groups of pigs with experimental abdominal aortic aneurysm. Group treated with atorvastatin and group without any pharmacological influencing. Comparing of aneurysmal growth rate. Evaluation of changes of the wall structure in both groups using a stereological tools. Review of published data. Results In our experimental work atorvastatin did not slow down the growth of the aneurysm. Effect was on the histological structure of the aneurysmatic wall. Wall structure of the aneurysm in group treated with atorvastatin was really close to wall without any...
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