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National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action
 Bláha, L. ; Vondráček, Jan ; Upham, B. L. ; Machala, M.
The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF.
Detailed record
The mechanisms of toxicity of polycyclic aromatic hydrocarbons mediated by cellular receptors
 Bláha, L. ; Vondráček, Jan ; Machala, M.
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Tumor-promoting activity of polycyclic aromatic hydrocarbons and extracts of air samples
 Bláha, L. ; Machala, M. ; Vondráček, Jan ; Kapplová, P.
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In vitro biochemical monitoring of organic contaminants present in atmosphere
 Machala, M. ; Bláha, L. ; Vondráček, Jan
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