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Účast monocytů a dendritických buněk v patogenezi celiakie
Tučková, Ludmila ; Palová-Jelínková, Lenka ; Rožková, D. ; Černá, M. ; Pecharová, Barbara ; Smythies, L. ; Smith, P. ; Dvořák, M. ; Fruhauf, P. ; Tlaskalová, Helena
This work studies the involvement of monocytes and dendritic cells in coelias cisease pathogenesis
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Stimulace P3MoC izolovaných z krve celiakálních pacientů gliadinovými fragmenty
Cinová, Jana ; Palová-Jelínková, Lenka ; Smythies, L. ; Černá, M. ; Pecharová, Barbara ; Dvořák, M. ; Fruhauf, P. ; Tlaskalová, Helena ; Smith, P. ; Tučková, Ludmila
We documented that gliadin digest stimulate PBMoC (isolated from celiac patients and healthydonors) to IL-8 and TNF alfa production through the NF-kappa B pathway. Monocytes expressed increased levels of dendritic cell markers
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Gliadin fragments induce phenotypic and functional maturation of human dendritic cells
Palová-Jelínková, Lenka ; Rožková, D. ; Pecharová, Barbara ; Bártová, J. ; Šedivá, A. ; Tlaskalová, Helena ; Spíšek, R. ; Tučková, Ludmila
Gliadin treatment also resulted in increased NF- B/DNA binding activity of p50 and p65 subunits. Taken together, gliadin peptides can contribute to overcoming the stage of unresponsiveness of immature DC by inducing phenotypic and functional DC maturation, resulting in more efficient processing and presentation of gliadin peptides to specific T lymphocytes
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The response of peripheral blood monocytes from celiac patients to gliadin peptides
Cinová, Jana ; Palová-Jelínková, Lenka ; Smythies, L. ; Černá, M. ; Pecharová, Barbara ; Dvořák, M. ; Fruhauf, P. ; Tlaskalová, Helena ; Smith, P. ; Tučková, Ludmila
We documented that gliadin digest stimulate PBMoC (isolated from celiac patients and healthydonors) to IL-8 and TNF alfa production through the NF-kappa B pathway. Monocytes expressed increased levels of dendritic cell markers
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