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Důsledky antiarytmických léčiv na srdeční energetiku
Převorovská, Světlana ; Maršík, František
The numerical model of the human cardiovascular system of pulsating type imitating the electrochemical and mechanical activity of the heart muscle was used to the simulation of the antiarrhythmic drugs on cardiac energy parameters. The numerical model developed at the Institute of Thermomechanics CAS gives the information about the antiarrhythmic drugs effects on cardiac energy parameters such as myocardial oxygen consumption, left ventricle stroke work. Cardiac oxygen demand is closely related to the cardiac afterload and therefore major goal of therapeutic treatment by way of antiarrhythmics use is to reduce systemic blood pressure.
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Hydrodynamika mozkomíšní tekutiny v páteřním kanálu
Kaczmarská, A. ; Vaněk, P. ; Maršík, František ; Převorovská, Světlana ; Otáhal, S. ; Otáhal, J.
In previous modelling study of the cerebrospinal fluid transportation we have shown that main source of the hydrodynamical resistance and compliance of the craniospinal system is cervical part of the spinal canal. The aim of our present study is the investigation of the influence of the cervical spine degenerative changes on the hydrodynamical parameters of the craniospinal system. The results obtained by using of the numerical model of the cerebrospinal fluid flow show the significant influence of the cervical spine degenerative changes on the hydrodynamics of this system.
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Numerická simulace účinků léčiv na srdeční akční potenciál
Převorovská, Světlana ; Maršík, František
The aim of the paper is a numerical simulation of the antiarrhythmic drugs effects on the cardiac action potential realized by the numerical model of the human cardiovascular system. The pulsating blood flow of the cardiovascular system is generated by the electrochemical and mechanical activity of heart muscle. This system is being modelled by four segments of the pulsating heart and by twenty three vascular segments of pulmonary and systemic circuits connected with the heart segments in series. The behaviour of the cardiovascular system is described by the heart rate and by its hemodynamical variables, i.e. the blood pressure, volume, flow, by the cardiovascular parameters such as the blood inertia, compliances and resistances in corresponding segments and by the physicochemical variables such as the cardiac action potential, the calcium, sodium and potassium ionts concentration.
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Modelování interakce kardiovaskulárního a respiračního systému
Převorovská, Světlana ; Maršík, František
The real cardiovascular and respiratory system in the model developed in the IT CAS is approximated by four segments of pulsating heart and twenty two vascular segments of pulmonary and systemic circuits including the coronary and bronchial circuits. Respiratory processes are considered at the level of pulmonary, tissue and brain segments. The interaction between the both systems is modelled by baroreflex and chemoreflex control loop.
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