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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
 Mašková, Ludmila ; Ždímal, Vladimír ; Ondráček, Jakub
Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et al., 2008). An important characteristic of particles dosed by MDI and DPI is particle size distribution (PSD) (Byron, 1990). This may vary depending on the formulation, but also on the temperature and relative humidity (RH) changes during the transport from the inhaler to the human respiratory tract. The aim of this study was to determine the influence of RH and inspiratory flow rates on the PSD\ncharacteristics and predict deposition efficiency of inhalable particles in the lungs.
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Size Distribution of Particles from Inhalers - Influence of Inspiratory Flow Rate and Humidity.
 Ondráčková, Lucie ; Ondráček, Jakub ; Kozáková, Jana ; Ždímal, Vladimír
The purpose of this research was to determine the influence of inspiratory flow rate and relative humidity on particle size distributions (PSDs) generated by three MDI inhalers (Flutiform, Fullhale and Ventolin) and one DPI inhaler (Spiriva). Particle size distributions were measured by APS 3321 (TSI, USA) for three different inspiratory flow rates – 30, 60 and 90 l/min. Hygroscopicity of particles was determined by comparing data obtained at laboratory conditions and at relative humidity of 90%. During the measurements of number PSDs by using of APS spectrometer, we recorded bimodal distributions for Flutiform and Fullhale and monomodal distributions for Ventolin and DPI Spiriva. The increasing inspiratory flow rate had a negligible effect on the position of modes of individual distributions. The differences in PSD, measured under ambient conditions and at RH of 90%, were also minimal and did not significantly affect the assumed probability of drug deposition.
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