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National Repository of Grey Literature

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T buňky mají zásadní úlohu při vytvoření protinádorové imunity u myší léčených protilátkou směrovanými konjugáty doxorubicinu a HPMA Mrkvan, Tomáš ; Kovář, Marek ; Etrych, Tomáš ; Strohalm, Jiří ; Plocová, Daniela ; Ulbrich, Karel ; Říhová, Blanka Anti-idiotype monoclonal antibody targeted N-(2-hydroxypropyl)methacrylamide copolymer bound doxorubicin is able to completely cure mice with BCL-1 B-cell leukemia. During the treatment the immune system is activated and effective long-term anti-tumor immunity is established. This immune reaction requires CD4+ and CD8+ cells. Detailed record

Exprese genů pro signalizaci apoptozy u buněk vystavených účinku HPMA konjugátů doxorubicinu Kovář, Lubomír ; Kovář, Marek ; Šťastný, Marek ; Strohalm, Jiří ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka We compared influence of hydrolytically and enzymatically cleavable conjugates based on N-(2-hydroxypropyl)methacrylamide on proliferatin activity and expression of mRNA of genes involved in apoptotic signalling pathway. We found elevated expression of Fas and bax mRNA in cells incubated with hydrolytically cleavable conjugates. Detailed record

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