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National Repository of Grey Literature

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The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats Koupilová, M. ; Patočka, J. ; Barth, Tomislav Effects of six analogs of AVP fragment 4-9 on cognitive impairment induced by cholinotoxin 3-quinuclidine benzilate (QB) or by noradrenotoxin (DSP-4) were investigated by means of Y-maze with aversive stimulation and T-maze with appetitive stimulation in Wistar rats. QB and DSP-4 induced a severe learning deficit in pretrained animals. Single preventive administration of the peptides reversed the QB and DSP-4 induced impairment of the retention of memory. Detailed record

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