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Terrorism - criminological aspects
Šumová, Barbora ; Kopečný, Zdeněk (advisor) ; Galovcová, Ingrid (referee)
Terrorism - criminological aspects Abstract The author deals with the term of terrorism and its criminological aspects. First, the definition of terrorism is defined, and then the readers are given a look into the history of this phenomenon. In accordance with the negative definition of this problem, the difference between the phenomenon of terrorism and extremism, organized crime or guerilla is described. The thesis also describes legal regulations in the Czech Republic and the United States of America as well as the potential risks for future development in the Czech area. In the key part of the work, the author deals with individual criminological aspects. The perpetrator of terrorism, both an individual and a terrorist organization, is approached on examples and through scientific studies. Then, the most frequent motives and causes of radicalization of these offenders are mentioned. The analysis of these factors is described from a psychological and sociological point of view. Part of the thesis is also devoted to the victims of this crime, both material and financial support, and the syndromes the survivors can face after the attack. At the end of the main part the different forms of terrorist attacks are described, focusing on bomb attack and hostage holding or kidnapping. And the conclusion of this...
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The role of new profibrotic molecules in the pathogenesis of systemic sclerosis.
Šumová, Barbora ; Šenolt, Ladislav (advisor) ; Funda, David (referee) ; Soukup, Tomáš (referee)
Systemic sclerosis (SSc) is immune-mediated fibrotic disease of unknown aetiology. Among the dominant pathogenic manifestations of SSc belong vascular changes, production of autoantibodies, activation of innate and adaptive immune responses and fibrotic processes. Transforming growth factor beta (TGF-β) has been identified as a central profibrotic factor stimulating fibroblasts to produce collagen. There are, however, a number of other mediators involved in the pathogenesis of SSc. Mutual activation and amplification of these molecules and their cascades may be a central mechanism of the SSc pathogenesis. Hedgehog (Hh) canonical signalling pathway plays an important role in the development and progression of fibrotic diseases. Expression of Hh target genes can be regulated through a canonical or non-canonical signalling cascade. The non-canonical activation of GLI transcription factors by TGF-β has not yet been investigated in SSc. The substantial part of this thesis is focused on the study of the mutual interaction of TGF-β and Hh signalling pathway. In vitro analysis confirmed TGF- β/SMAD3 dependent activation of GLI2 in dermal fibroblasts. Fibroblasts specific knockout of GLI2 prevented the development of experimental fibrosis in vivo. Combined targeting of canonical and non-canonical Hh...
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