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Functional Imaging Methods of Lung Carcinoma
Baráková, Táňa ; Baxa, Jan (advisor) ; Eliáš, Pavel (referee) ; Čtvrtlík, Filip (referee)
Topic: Functional imaging methods of lung cancer MUDr. Táňa Baráková, Klinika zobrazovacích metod FN Plzeň Introduction: The aim of my work was to assess the use of direct quantification of dual-energy CT (DE-CT) radiation in the diagnosis and monitoring of non-small cell lung cancer (NSCLC) therapy. The work consists of three studies that were performed on Department of imaging methods. The main objectives were to assess the contribution of iodine quantification from DE-CT examinations, to verify the setting and to incorporate the DE-CT examination of the chest into a routine investigation. Furthermore, to investigate the possible benefit of dual- phase DE-CT in evaluating both primary non-small cell lung cancer itself and lymph nodes in terms of iodine and size relationship in chemotherapy or targeted therapy, and finally to investigate the possible benefit of staging FDG-PET / CT to evaluate the effect of therapy on lymph nodes. Methodics: In all presented studies, the same DE-CT protocol was used in the early (arterial) and late (venous) stages. Using a dedicated software prototype, iodine content analysis was performed as the equivalent of blood circulation in lymph nodes and tumors. The main evaluated parameters were iodine content (mg), iodine uptake (mg / ml) and ratio of arterial enhancement...
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Use the Contrast-Enhanced Ultrasoun in the Morning of the Effect of Liver Tumors Treatment by Radiofrequency ablation
Korčáková, Eva ; Mírka, Hynek (advisor) ; Mechl, Marek (referee) ; Čtvrtlík, Filip (referee)
Use the contrast-enhanced ultrasound in the monitoring of the effect of liver tumors treatment by radiofrequency ablation. Summary High quality imaging is crucial for the treatment of liver tumors by the percutaneous radiofrequency ablation. Imaging methods are used for planning, navigation of the intervention and monitoring after treatment. An early detection of residual tumor tissue or recurrence affect significantly the quality of life and life expectancy of the patients. Contrast enhanced ultrasound (CEUS) seems to be a suitable method for monitoring the locoregional treatment mainly because zero radiation impact on patient and allows the highly accurate real-time assessment of vascularization. The aim of my work was to verify the ability of CEUS to detect residual tumor tissue or tumor recurrence in the field of changes after radiofrequency ablation. We evaluated the group of 73 patients, who were treated by radiofrequency ablation (RFA) for liver cancer. CEUS reached in our group the overal sensitivity 77.27 %, and in the group of colorectal cancer metastases 83.33 %. We compared CEUS with results of computed tomography (CT), which is the most commonly used method for monitoring the treatment. CEUS and CT results are similar. Based on this study, the CEUS appears to be a suitable method for monitoring...
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Optimization of Exposure Values in Computed Tomography. Perfusion CT of the Brain
Bejček, Jiří ; Baxa, Jan (advisor) ; Čtvrtlík, Filip (referee) ; Weichet, Jiří (referee)
Topic: Optimization of exposure values in computed tomography MUDr. Jiří Bejček, Department of Imaging Methods, FH Pilsen Introduction: Stroke is one of the most frequent diseases in the human population, the second most frequent cause of death in economically developed countries. Early diagnosis and rapid treatment play a key role. Computed tomography can be used to diagnose stroke and select optimal therapy for the patient. However, rising CT scans increase the radiation exposure of the population. Aim: The aim of this work was to analyze the stroke protocol used in the Department of Imaging Methods in Pilsen, which is used in the diagnosis of acute cerebral ischemia. In addition, the aim was to design a modification of the protocol in order to reduce the radiation exposure, maintain the diagnostic quality of the image for evaluation and verify the feasibility in daily routine. Methods: The circulation times of the original (test) protocol were analyzed retrospectively. Based on this analysis, a shortened protocol was set according to test bolus performed in CT angiography. 134 patients were examined with this protocol. Subsequently, a reduction of the voltage to 70 kV was performed and 108 patients were examined. Further protocol adjustments were made according to the width of test bolus curve. 38...
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Functional Imaging Methods of Lung Carcinoma
Baráková, Táňa ; Baxa, Jan (advisor) ; Eliáš, Pavel (referee) ; Čtvrtlík, Filip (referee)
Topic: Functional imaging methods of lung cancer MUDr. Táňa Baráková, Klinika zobrazovacích metod FN Plzeň Introduction: The aim of my work was to assess the use of direct quantification of dual-energy CT (DE-CT) radiation in the diagnosis and monitoring of non-small cell lung cancer (NSCLC) therapy. The work consists of three studies that were performed on Department of imaging methods. The main objectives were to assess the contribution of iodine quantification from DE-CT examinations, to verify the setting and to incorporate the DE-CT examination of the chest into a routine investigation. Furthermore, to investigate the possible benefit of dual- phase DE-CT in evaluating both primary non-small cell lung cancer itself and lymph nodes in terms of iodine and size relationship in chemotherapy or targeted therapy, and finally to investigate the possible benefit of staging FDG-PET / CT to evaluate the effect of therapy on lymph nodes. Methodics: In all presented studies, the same DE-CT protocol was used in the early (arterial) and late (venous) stages. Using a dedicated software prototype, iodine content analysis was performed as the equivalent of blood circulation in lymph nodes and tumors. The main evaluated parameters were iodine content (mg), iodine uptake (mg / ml) and ratio of arterial enhancement...
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