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Pharmacokinetic modelling in Positron Emission Tomography
 Čaňková, Lenka ; Jiřík, Radovan (referee) ; Mézl, Martin (advisor)
This bachelor thesis deals with pharmacokinetic compartmental modelling in positron emission tomography. It includes a description of the basic pharmacokinetic variables and models. Models for selected radiopharmaceuticals are theoretically developed. Simulations of different organs in the Simulink environment have been performed for the radiopharmaceutical 18F-FDG. A brain slice model for the radiopharmaceutical [11C]-PS13 was created. Estimation of constants and optimization of models based on real data was performed. Subsequently, graphs of radiopharmaceutical concentrations as a function of time were plotted and described.
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