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Evaluation of compressibility of acetylsalicylic acid
Pavelková, Petra ; Řehula, Milan (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Petra Pavelková Consultant: Doc. RNDr. Milan Řehula, CSc. Evaluation of compressibility of acetylsalicylic acid The aim of this thesis was evaluation of stability of acetylsalicylic acid from crystallographic aspect during compression process and to determine compressibility of this medical substance in the same time. For this purpose it was performed measurement of differential scanning calorimetry in range from - 30 žC to 220 žC by a speed of heating 10 žC/min. and cooling - 20 žC/min.. Further, the compaction equation, force-displacement record at compression forces ranging from 5 to 40 kN, and the stress relaxation at compression forces of 5, 10 and 15 kN were used. Measurement took place in specific conditions, which are described below. The experimental results showed following conclusions: The relation between the parameter E3 and compression force (LS) is non- linear and described by the equation: ESD3 = 0,086 LS + 0,013 LS2 - 0,211 R2 = 0,9999 The relation between plasticity and compression force (LS) is also non-linear and described by the equation: Pl = - 3,603 LS + 0,049 LS2 + 85,506 R2 = 0,9903 Values of the parameter PL show that ASA has a poor compressibility. At a...
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Evaluation of compressibility of ibuprofen
Kolarczyková, Barbora ; Řehula, Milan (advisor) ; Svačinová, Petra (referee)
The aim of this study is to determine whether dissociation and a change of crystal modification of ibuprofen do not arise during the compression process. For this purpose an evaluation by means of equation of compression, evaluation by stress relaxation, evaluation by force-distance diagram and evaluation by differential scanning calorimetry is accomplished. The equation of compression developed by department of pharmaceutical technology describes the process of compression by parameters of three phases: phase before compression, phase elastic and plastic deformation. The test of stress relaxation was performed at compression force of 5, 10 and 15 kN. During the evaluation of a force-distance record phase of compression and relaxation of tablet was examined from energetic point of view at compression force of 5, 10, 15, 20, 25, 30, 35, 40 kN. These tablets were also evaluated by means of differential scanning calorimetry. Two basic conclusions arise out of the measured results: during the compression process dissociation or modification of crystal form if ibuprofen and simultaneously low plasticity of medicinal substance was found out (at compression force of 15kN plasticity was only 47 %).
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A study of co-processed dry binders with lactose and microcrystalline cellulose.
Nezbedová, Andrea ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
The thesis compares two coprocessed dry binders with identical content MicroceLac® 100 and DisintequikTM MCC 25. The substances content α-lactose monohydrate and microcrystalline cellulose in the same ratio 3:1. They were evaluated from the aspect of powder's properties, compressibility and mechanical properties of compressed tablets (tensile strength and disintegration time). The influence factors were the compression force and the addition of the lubricants magnesium stearate and sodium stearyl fumarate in 1 % concentration. DisintequikTM MCC 25 showed higher flowability and higher bulk and tapped density than MicroceLac® 100. The value of all evaluated energies increased with compression force, but the plasticity decreased. MicroceLac® 100 indicated higher values of total energy of compression and energy of friction. DisintequickTM MCC 25 showed higher values of plasticity energy, energy of compression and plasticity. The elasticity energy was comparable in both substances. The addition of lubricants didn't affect the tested energies or plasticity. The tensile strength and the disintegration time increased with compression force. The tensile strength of tablets from both coprocessed dry binders was almost identical and was reduced by lubricants. The disintegration time was significantly longer...
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A study of the compaction process and the properties of tablets from different types of calcium hydrogen phosphate.
Koryťáková, Lenka ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
The thesis evaluates anhydrous and dihydrate calcium hydrogen phosphate from the view point of the tensile strength, disintegration time of tablets depending on the compression force. Two firm products - Anhydrous Emcompress® and Di-Cafos® A 60 are used as anhydrate and Emcompress® is used as dihydrate. A compression force together with lubricants (magnesium stearate, sodium stearyl fumarate) and an addition of microcrystalline cellulose (Vivapur® 102) are the influential factors. In addition to the characteristics of tablets, the energy balance of compression is also evaluated. Used compression forces were 12, 16 and 20 kN. The compression force 12 kN was used for the mixtures containing Vivapur® 102. Total energy of compression, energy for friction and energy accumulated by tablet after compression increased with compression force. The highest values were at Anhydrous Emcompress® , an addition Vivapur® 102 increased these values. There weren't more significant differences among the values of decompression energy. Plasticity decreased with the growing compression force, the highest values were at Anhydrous Emcompress® , Vivapur® 102 increased that. Tensile strength increased with compression force, Emcompress® provided the strongest tablets, Di-Cafos® A 60 provided at least strong tablets. Vivapur...
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A study of the compaction process and the properties of tablets containing microcrystalline cellulose and colloidal silicon dioxide
Louženská, Markéta ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
The thesis deals with the comparison of compressibility and properties of tablets containing silicified microcrystalline cellulose and physical mixtures of microcrystalline cellulose with different types of colloidal silicon dioxide. The used excipients were silicified microcrystalline cellulose Prosolv® SMCC 90, microcrystalline cellulose Avicel® PH-102 and colloidal silicon dioxide Aerosil® 200 and 255. Tablets were compressed at three compression forces 2.5, 3 and 3.5 kN. The energy profile of compression, the tensile strength of tablets and the disintegration time of tablets were evaluated. The effect of 1 % magnesium stearate on these parameters under various mixing conditions and its homogenity in the tablet were evaluated. Total energy of compression increased with the growing compression force, it was the highest at Prosolv® SMCC 90. Plasticity decreased with compression force, mixtures of Avicel® PH-102 with both types of Aerosil showed its the highest values. These mixtures provided tablets with lower strength than Avicel® PH-102 and Prosolv® SMCC 90. Disintegration time of tablets increased with the growing compression force and it was longer in the case of tablets from Prosolv® SMCC 90 and Avicel® PH-102. The addition of magnesium stearate decreased tensile strength of tablets most in...
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Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation
Matyášová, Andrea ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Andrea Matyášová Title of Thesis: Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation This thesis is aimed at the evaluation and comparison of excipients used in production of tablets. The compaction process of these excipients was evaluated using the parameters of the compaction equation. The mixtures of four fillers in various ratios were evaluated. These mixtures contained also theophylline as model drug and magnesium stearate as lubricant. The used three-exponential equation was previously developed by doc. RNDr. Milan Řehula, CSc. By using this compaction equation the volume reductions, speeds of volume reductions and consumed energies were calculated and evaluated. The results of this work showed that particular used fillers have different effect on the compaction process flow. That is caused primarily by different behavior of these materials during compaction and by formation of different types of bonds. Also the need of thorough cleaning and drying of compaction aid before compaction was confirmed.
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Validation of a new method for the evaluation of stress relaxation of tablets
Černá, Pavlína ; Řehula, Milan (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Supervisor: Doc. RNDr. Milan Řehula, CSc. Title of Dissertation: Validation of a new method for the evaluation of stress relaxation of tablets Keywords: tablets, stress relaxation test, elastic and plastic deformation The theoretical part of this thesis deals with the elastic relaxation of tablets. It describes various methods used in the evaluation of elastic recovery of tablets. The present work explores the factors affecting the elastic relaxation of tablets. The experimental part is focused on the stress relaxation test. Until present only one delay was studied. This work studies the stress relaxation after relieving tablet. The parameters A2, T2 and P2 were reviewed. The relationship between the parameters P2 and compression force relief were studied. For experiments microcrystalline cellulose Avicel PH 102 (MCC) was used. Tablets were compressed in a device used for testing the strength of the material in pressure and tension T1-FRO 50. For the determination of the stress relaxation test, the tablets were compressed with 180 sec first delay. The second delay was always 60 sec but it was measured from certain decrease of pressure (7 kN, 6 kN, 5 kN, 4 kN, 3 kN, 2 kN, 1 kN and 0.1 kN). To...
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The Fugger and their contacts with Hapsburgs in 15th and 16th century
Svačinová, Petra ; Čechura, Jaroslav (advisor) ; Županič, Jan (referee)
The aim of this thesis is to demonstrate the political and financial cooperation between the merchants of the House of Fugger and the rulers of the House of Habsburg, in particular in the second half of the 15th and the first half of the 16th centuries. The thesis examines the relationship between the two houses in the context of general European developments. The thesis describes the arrival of Hans, the first of the Fuggers, to Augsburg in 1367 and then the 'golden age' of the Fugger family under the helm of Jakob Fugger, known as the Rich. This period marked the closest relations between the Fuggers and the Habsburgs, as evidenced by the coronations of Maximilian I and Charles V. Following the death of Jakob, Anton Fugger took over the family business. Although the wealth of the Fugger family peaked in 1546, this period was characterized by a slow dissolution of the partnership with the Habsburgs. At the same time, the Fuggers started an intended retreat from mining and finance and began to move into distance-trade and real estate purchases. Anton was no longer able to maintain the position of 'the Emperor's banker' once attained by his uncle and refused to be just a piece on the chessboard of Habsburg interests. His 'escape to the countryside' was, it seems, a thought-through strategy to...
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Determining the compression behaviour of mannitol and sorbitol.
Svačinová, Petra ; Špaček, Vladimír (referee) ; Řehula, Milan (advisor)
This diploma thesis is summarize the tablet's parameters such as pressing, crushing and the kinetics of the tablets. Moreover, the crushing force, tensile strenght, volume crushing force, trajectory, crushing energy, volume crushing energy and relations between compression force and compression pressure, crushing force and influence of compression force onto the tensile strenght, crushing force and volume crushing force. These characteristics have been investigated by using tablets made of microcrystalline celulosis called Avicel 103 and Avicel 301, saccharosis, sorbitole and mannitole (Pearlitole). Tablets were pressed with the using of various pressing pressures and then crushed. Parameters and relations inbetween them are followed by the force-trajectory data record, that has been acquired during the process of crushing. As the results are, the dependance among crushing and pressing forces is linear in the latitude of 4 - 15 kN, therefore for other enumerations I used the values gained during these measurements. Parameters of the destructing process for the numbers of crushing force, tensile strenght ans volume destruction energy were the highest with usage of Avicel 103 and then descending through Avicel 301, sorbitole, pearlitole and saccharose. Tensile strenght was descending in order:...
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The tap water in drinking regime for pupils of upper primary schools and the possibility of increasing consuption.
SVAČINOVÁ, Petra
This bachelor work (thesis) is focused on the importance of drinking tap water in the second grade of primary school and the posibility of increasing its consumption. The theoretical part deals with water resources on Earth and the water content in the body and foods, as well as differences in tap water from bottled water. The bachelor work is also focused on recording differences between these waters and consumption opinions. The main method of practical part was own questionnaire. This part provides some key findings, especially in the usage energy drinks to cover the common needs fluids at chosen age.
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